Department of Surgery, Division of Surgical Oncology, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, 4th Floor, Miami, FL 31336, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, 4th Floor, Miami, FL 31336, USA.
Department of Surgery, Division of Surgical Oncology, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, 4th Floor, Miami, FL 31336, USA.
Adv Surg. 2023 Sep;57(1):1-14. doi: 10.1016/j.yasu.2023.03.001. Epub 2023 May 10.
Racial/ethnic and socioeconomic disparities seen in triple-negative breast cancer (TNBC) have prompted questions regarding the role of genetic ancestry in breast cancer (BC) subtype development, tumor biology, and ultimately prognosis. The causes of disparities in TNBC are influenced greatly by both sociopolitical factors and genetic ancestry, and now, the potential genomic underpinnings of social factors. To comprehensively understand disparities in TNBC, it is critical to take a translational epidemiologic approach that takes into account genomic and non-genomic factors. Understanding the interplay between genetic ancestry and social genomics and their proportional influence on outcomes can guide our priorities for screening, diagnosis, and interventions for this aggressive BC subtype.
在三阴性乳腺癌（TNBC）中存在的种族/民族和社会经济差异促使人们对遗传背景在乳腺癌（BC）亚型发展、肿瘤生物学以及最终预后中的作用产生疑问。TNBC 差异的原因受到社会政治因素和遗传背景的极大影响，以及现在社会因素的潜在基因组基础的影响。为了全面了解 TNBC 中的差异，采用考虑基因组和非基因组因素的转化流行病学方法至关重要。了解遗传背景和社会基因组学之间的相互作用及其对结果的比例影响，可以指导我们对这种侵袭性 BC 亚型进行筛查、诊断和干预的优先事项。
