West Virginia University.
Mount Sinai Morningside and Mount Sinai West, Department of Pathology, 1000 Tenth Avenue, First floor, Room G183, New York, NY 10019, USA.
Surg Pathol Clin. 2023 Sep;16(3):599-608. doi: 10.1016/j.path.2023.04.012. Epub 2023 Jun 23.
Intrahepatic cholangiocarcinoma is a challenge to the practicing surgical pathologist for several reasons. It is rare in many parts of the world, and thus practical exposure may be limited. Related to the fact of its rarity is the fact that more common tumors which frequently metastasize to the liver can be morphologically indistinguishable (eg, pancreatic ductal adenocarcinoma). Immunohistochemical testing is generally non-contributory in this context. Other difficulties arise from the protean morphologic manifestations of cholangiocarcinoma (ie, small duct vs. large duct) and the existence of combined cholangiocarcinoma and hepatocellular carcinoma. These, and other issues of concern to the practicing diagnostic pathologist are discussed herein.
肝内胆管癌对从事外科病理工作的医生来说是一个挑战，原因有几个。在世界上许多地区，它都很罕见，因此实际接触可能有限。与罕见的事实相关的是，更常见的经常转移到肝脏的肿瘤在形态上可能无法区分（例如，胰腺导管腺癌）。在这种情况下，免疫组织化学检测通常没有帮助。其他困难来自胆管癌的多形性形态表现（即小胆管与大胆管）以及存在胆管细胞癌和肝细胞癌的混合癌。本文讨论了这些问题以及其他困扰临床病理医生的问题。
