Koerner F, Bossi E, Wetzel C, Flury B
Graefes Arch Clin Exp Ophthalmol. 1986;224(1):40-5. doi: 10.1007/BF02144132.
The clinical and laboratory data on 140 premature infants, 74 cases with retinopathy of prematurity (ROP) and 66 control cases without ROP, were correlated with ROP grades of increasing severity. By using multiple linear regression (MLR), it is shown that for predicting ROP grades the importance of certain variables varies considerably depending on the gestational age. Below 32 weeks of gestation, acidosis, hyperoxemia, gestational age, pathologic paCO2 levels, and multiple birth are strong regressors. Above 31 weeks, the most important regressors are multiple birth and acidosis, while gestational age and duration of FiO2 greater than 0.4 are much less influential. Blood transfusions and artificial ventilation do not seem important in the MLR of either group. When ROP is regressed on the number of paO2 values above 100 torr and gestational age or on the number of paCO2 values above 50 torr and gestational age, the regression coefficients of these variables drop to near zero at a gestational age of about 32 weeks. This loss of weight of the two variables paO2 and paCO2 with increasing gestational age coincides with a comparable drop of the relative incidence of ROP and the relative incidence of immature retinal vessels. It is hypothesized that it is the proportion of infants with an immature retinal vasculature in populations of given gestational ages rather than the gestational age itself which is responsible for the widely varying importance of certain factors during the development of ROP.
140例早产儿的临床和实验室数据，其中74例患有早产儿视网膜病变（ROP），66例为无ROP的对照病例，这些数据与严重程度不断增加的ROP分级相关。通过多元线性回归（MLR）分析表明，对于预测ROP分级，某些变量的重要性会因胎龄的不同而有很大差异。在妊娠32周以下，酸中毒、高氧血症、胎龄、病理性二氧化碳分压水平和多胎妊娠是强有力的回归因素。在31周以上，最重要的回归因素是多胎妊娠和酸中毒，而胎龄和吸入氧分数（FiO2）大于0.4的持续时间影响则小得多。在两组的MLR分析中，输血和人工通气似乎并不重要。当将ROP与高于100托的动脉血氧分压（paO2）值数量和胎龄，或与高于50托的动脉血二氧化碳分压（paCO2）值数量和胎龄进行回归分析时，在胎龄约32周时，这些变量的回归系数降至接近零。随着胎龄增加，paO2和paCO2这两个变量影响力的下降，与ROP相对发病率和未成熟视网膜血管相对发病率的相应下降相吻合。据推测，在特定胎龄人群中，视网膜血管未成熟的婴儿比例，而非胎龄本身，是导致ROP发展过程中某些因素重要性差异巨大的原因。
