Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Office of VP Research Development, Arizona State University, Tempe, AZ, USA.
BMJ Open. 2023 Aug 3;13(8):e072627. doi: 10.1136/bmjopen-2023-072627.
This study investigated the seroprevalence of SARS-CoV-2 antibodies among adults over 18 years.
Prospective cohort study.
A large public university.
This study took volunteers over 5 days and recruited 1064 adult participants.
Seroprevalence of SARS-CoV-2-specific antibodies due to previous exposure to SARS-CoV-2 and/or vaccination.
The seroprevalence of the antireceptor binding domain (RBD) antibody was 90% by a lateral flow assay and 88% by a semiquantitative chemiluminescent immunoassay. The seroprevalence for antinucleocapsid was 20%. In addition, individuals with previous natural COVID-19 infection plus vaccination had higher anti-RBD antibody levels compared with those who had vaccination only or infection only. Individuals who had a breakthrough infection had the highest anti-RBD antibody levels.
Accurate estimates of the cumulative incidence of SARS-CoV-2 infection can inform the development of university risk mitigation protocols such as encouraging booster shots, extending mask mandates or reverting to online classes. It could help us to have clear guidance to act at the first sign of the next surge as well, especially since there is a surge of COVID-19 subvariant infections.
本研究调查了 18 岁以上成年人中 SARS-CoV-2 抗体的血清阳性率。
前瞻性队列研究。
一所大型公立大学。
本研究在 5 天内招募志愿者，共招募了 1064 名成年参与者。
由于先前暴露于 SARS-CoV-2 和/或接种疫苗而导致的 SARS-CoV-2 特异性抗体的血清阳性率。
通过侧向流动检测，抗受体结合域（RBD）抗体的血清阳性率为 90%，通过半定量化学发光免疫分析的血清阳性率为 88%。抗核衣壳的血清阳性率为 20%。此外，既往自然感染 COVID-19 加接种疫苗的个体的抗 RBD 抗体水平高于仅接种疫苗或仅感染的个体。突破性感染的个体具有最高的抗 RBD 抗体水平。
准确估计 SARS-CoV-2 感染的累积发病率，可以为大学制定风险缓解协议提供信息，例如鼓励加强针、延长口罩强制令或恢复网课。这有助于我们在下一次疫情爆发的早期阶段提供明确的指导，尤其是在 COVID-19 亚变体感染激增的情况下。
