Department of Geriatric Cardiology, Xiangya Hospital, Central South University, Changsha, 41008, China.
Department of Cardiology, Xiangya Hospital, Central South University, #87 Xiangya Road, Kaifu District, Changsha, 410008, Hunan, China.
J Physiol Biochem. 2023 Nov;79(4):745-756. doi: 10.1007/s13105-023-00971-3. Epub 2023 Aug 4.
Continuously prolonged cardiac hypertrophy results in maladaptive myocardial remodeling, which affects cardiac function and can eventually lead to heart failure. Short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, have been reported to be associated with cardiovascular diseases (CVD). Gut microbiota may mediate between dietary fiber and SCFA effects on cardiac hypertrophy. The mice model of isoproterenol (ISO)-induced cardiac hypertrophy was constructed and verified for physiological, functional, and fibrotic alterations in this study. Both high-fiber and acetate diet improved physiological indexes, ameliorated cardiac functions, and relieved fibrotic alterations in model mice hearts; collectively, cardiac hypertrophy in mice receiving both high-fiber and acetate diet improved. Following 16s rDNA sequencing and integrative bioinformatics, analyses indicated that both high-fiber and acetate diet caused alterations in mice gut microbiota compared with the ISO group, including OTU composition and abundance. In conclusion, high-fiber and acetate diet improve the physiological status, cardiac functions, and fibrotic alterations in ISO-induced hypertrophic mice. Besides, considering the alterations in mice gut microbiota in response to single ISO, both high-fiber and acetate diet treatment, gut microbiota might mediate the favorable benefits of both high-fiber and acetate diet on cardiac hypertrophy.
持续延长的心肌肥厚会导致适应性心肌重构，影响心脏功能，最终导致心力衰竭。短链脂肪酸（SCFAs），包括乙酸盐、丙酸盐和丁酸盐，已被报道与心血管疾病（CVD）有关。肠道微生物群可能在膳食纤维和 SCFA 对心肌肥厚的影响之间起介导作用。本研究构建了异丙肾上腺素（ISO）诱导的心肌肥厚小鼠模型，并验证了其在生理、功能和纤维化改变方面的变化。高纤维和乙酸盐饮食均改善了模型小鼠的生理指标，改善了心脏功能，并缓解了心脏纤维化改变；总的来说，接受高纤维和乙酸盐饮食的小鼠的心肌肥厚得到了改善。通过 16s rDNA 测序和综合生物信息学分析，结果表明，与 ISO 组相比，高纤维和乙酸盐饮食均导致了小鼠肠道微生物群的改变，包括 OTU 组成和丰度。总之，高纤维和乙酸盐饮食改善了 ISO 诱导的肥厚小鼠的生理状态、心脏功能和纤维化改变。此外，考虑到单一 ISO 对小鼠肠道微生物群的改变，高纤维和乙酸盐饮食治疗均导致了肠道微生物群的改变，这可能介导了高纤维和乙酸盐饮食对心肌肥厚的有益作用。
