编码一种可能的神经烟碱型乙酰胆碱受体α亚基的cDNA克隆的分离。
Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor alpha-subunit.
作者信息
Boulter J, Evans K, Goldman D, Martin G, Treco D, Heinemann S, Patrick J
出版信息
Nature. 1986;319(6052):368-74. doi: 10.1038/319368a0.
DOI:10.1038/319368a0
PMID:3753746
Abstract
We have isolated a complementary DNA clone containing sequences homologous to those encoding the alpha-subunit of a mouse muscle nicotinic acetylcholine receptor. Based on the structural similarities between the encoded protein and the muscle acetylcholine receptor alpha-subunit, and the presence of hybridizing RNA species in the brain, we propose that this clone codes for a neural nicotinic acetylcholine receptor alpha-subunit.
摘要
我们分离出了一个互补DNA克隆，其包含的序列与编码小鼠肌肉烟碱型乙酰胆碱受体α亚基的序列同源。基于编码蛋白与肌肉乙酰胆碱受体α亚基之间的结构相似性，以及大脑中存在杂交RNA种类，我们提出该克隆编码一种神经烟碱型乙酰胆碱受体α亚基。
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