新鲜水果摄入与中国成年人慢性阻塞性肺疾病相关住院和死亡风险的关联：一项前瞻性队列研究。

Association between fresh fruit consumption and the risk of chronic obstructive pulmonary disease-related hospitalization and death in Chinese adults: A prospective cohort study.

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China.

Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing 100191, China.

出版信息

Chin Med J (Engl). 2023 Oct 5;136(19):2316-2323. doi: 10.1097/CM9.0000000000002591.

DOI:10.1097/CM9.0000000000002591

PMID:37537725

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10538915/

Abstract

BACKGROUND

Existing evidence suggests that fruit consumption is a significant influencing factor for chronic obstructive pulmonary disease (COPD), but this is unclear in the Chinese population. We examined the association of fresh fruit consumption with the risk of COPD-related hospitalization and death in a nationwide, population-based prospective cohort from China.

METHODS

Between 2004 and 2008, the China Kadoorie Biobank recruited >0.5 million adults aged 30 to 79 years from ten diverse regions across China. After excluding individuals diagnosed with major chronic diseases and prevalent COPD, the prospective analysis included 421,428 participants. Cox regression was used to calculate the hazard ratios (HRs) for the association between fresh fruit consumption and risk of COPD-related hospitalization and death, with adjustment for established and potential confounders.

RESULTS

During a mean follow-up of 10.9 years, 11,292 COPD hospitalization events and deaths were documented, with an overall incidence rate of 2.47/1000 person-years. Participants who consumed fresh fruit daily had a 22% lower risk of COPD-related hospitalization and death compared with non-consumers (HR = 0.78, 95% confidence interval [CI]: 0.71-0.87). The inverse association between fresh fruit consumption and COPD-related hospitalization and death was stronger among non-current smokers and participants with normal body mass index (BMI) (18.5 kg/m 2 ≤ BMI < 24.0 kg/m 2 ); the corresponding HRs for daily fresh fruit consumption were 0.78 (95% CI: 0.68-0.89) and 0.69 (95% CI: 0.59-0.79) compared with their counterparts, respectively.

CONCLUSIONS

High-frequency fruit consumption was associated with a lower risk of COPD in Chinese adults. Increasing fruit consumption, together with cigarette cessation and weight control, should be considered in the prevention and management of COPD.

摘要

背景

现有证据表明，水果摄入是慢性阻塞性肺疾病（COPD）的一个重要影响因素，但这在中国人群中尚不清楚。我们在中国进行了一项全国性、基于人群的前瞻性队列研究，以研究新鲜水果摄入与 COPD 相关住院和死亡风险的关系。

方法

在 2004 年至 2008 年间，中国慢性病前瞻性研究从中国十个不同地区招募了超过 500 万名 30 至 79 岁的成年人。排除患有主要慢性疾病和现患 COPD 的个体后，前瞻性分析包括 421428 名参与者。使用 Cox 回归计算新鲜水果摄入与 COPD 相关住院和死亡风险之间的风险比（HR），并调整了已确定和潜在的混杂因素。

结果

在平均 10.9 年的随访期间，记录了 11292 例 COPD 住院事件和死亡，总发病率为 2.47/1000 人年。与非食用者相比，每天食用新鲜水果的参与者 COPD 相关住院和死亡风险降低 22%（HR=0.78，95%置信区间[CI]：0.71-0.87）。在非当前吸烟者和正常体重指数（BMI）（18.5kg/m 2 ≤ BMI < 24.0kg/m 2 ）参与者中，新鲜水果摄入与 COPD 相关住院和死亡之间的反比关系更强；相应的每日新鲜水果摄入 HR 分别为 0.78（95% CI：0.68-0.89）和 0.69（95% CI：0.59-0.79）。