Park Marn Joon, Han Kyung-Do, Cho Jae Hoon, Choi Ji Ho
Department of Otorhinolaryngology-Head and Neck Surgery, Inha University Hospital, School of Medicine, Inha University, Incheon, Republic of Korea.
Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.
Front Oncol. 2023 Jul 19;13:1214279. doi: 10.3389/fonc.2023.1214279. eCollection 2023.
Obstructive sleep apnea (OSA) is known to increase the risk of various cancers. By analyzing the Korea National Health Insurance Service (KNHIS) registry, the impact of OSA on the lung cancer incidence was analyzed in a retrospective cohort group.
A retrospective cohort of adult patients newly registered with OSA in the KNHIS data from 2007 to 2017 was included and observed until December 2019 (12 years). The main outcome measure was newly diagnosed lung cancer. The control group was set with age and sex that matched those in the OSA group.
The hazard ratio (HR) of OSA for lung cancer incidence showed a significantly reduced HR of 0.87 (95% CI, 0.82-0.93). The observed significance of this finding was limited to male OSA patients [HR, 0.84 (95% CI, 0.78-0.90)], while no significant association was found in female OSA patients [HR, 1.05 (95% CI, 0.91-1.21)], irrespective of their age.
OSA patients have a lower risk of developing lung cancer, but this risk reduction is gender-specific, as female OSA patients do not show a reduction in hazard ratio.
已知阻塞性睡眠呼吸暂停（OSA）会增加患各种癌症的风险。通过分析韩国国民健康保险服务（KNHIS）登记处的数据，对一个回顾性队列组中OSA对肺癌发病率的影响进行了分析。
纳入2007年至2017年在KNHIS数据中首次登记患有OSA的成年患者回顾性队列，并观察至2019年12月（共12年）。主要观察指标是新诊断的肺癌。对照组按年龄和性别与OSA组匹配设置。
OSA与肺癌发病率的风险比（HR）显示显著降低，HR为0.87（95%置信区间，0.82 - 0.93）。这一发现的观察显著性仅限于男性OSA患者[HR，0.84（95%置信区间，0.78 - 0.90）]，而女性OSA患者未发现显著关联[HR，1.05（95%置信区间，0.91 - 1.21）]，无论其年龄如何。
OSA患者患肺癌的风险较低，但这种风险降低具有性别特异性，因为女性OSA患者的风险比未降低。
