Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Konkuk University, Seoul, Republic of Korea.
Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.
PLoS One. 2020 Nov 12;15(11):e0241598. doi: 10.1371/journal.pone.0241598. eCollection 2020.
The association between obstructive sleep apnea (OSA) and malignant brain tumors has yet to be fully investigated. Therefore, the purpose of this study was to elucidate the effect of OSA on brain tumor incidence based on the Korea National Health Insurance Service (KNHIS) dataset. The KNHIS data between 2007 and 2014 were analyzed, and the primary endpoint was newly diagnosed malignant brain tumor. A total of 198,574 subjects aged ≥ 20 years with newly diagnosed OSA were enrolled in the study, and 992,870 individuals were selected as a control group based on propensity score matching (PSM) by gender and age. The average follow-up duration was 4.8 ± 2.3 years. The hazard ratios (HRs) for brain tumor for patients with OSA were 1.78 (95% confidence interval [CI]: 1.42-2.21) in Model 1 (not adjusted with any covariate) and 1.67 (95% CI: 1.34-2.09) in Model 2 (adjusted for income level, diabetes, hypertension, dyslipidemia, and COPD). In subgroup analysis by gender, the odds ratios (OR) of OSA were 1.82 (95% CI: 1.41-2.33) in men and 1.26 (95% CI: 0.74-2.03) in women. The ORs were 1.97 (95% CI: 1.15-3.24) in the older (age ≥ 65 years) group, 1.66 (95% CI: 1.25-2.17) in the middle-aged (40 ≤ age < 65 years) group, and 1.41 (0.78-2.44) in the young (20 ≤ age < 40 years) group. In conclusion, OSA may increase the incidence of brain tumors.
阻塞性睡眠呼吸暂停（OSA）与恶性脑肿瘤之间的关联尚未得到充分研究。因此，本研究旨在基于韩国国家健康保险服务（KNHIS）数据集阐明 OSA 对脑肿瘤发病率的影响。分析了 2007 年至 2014 年的 KNHIS 数据，主要终点是新诊断的恶性脑肿瘤。共纳入 198574 例年龄≥20 岁且新诊断为 OSA 的患者作为研究对象，并根据性别和年龄通过倾向评分匹配（PSM）选择了 992870 名个体作为对照组。平均随访时间为 4.8±2.3 年。模型 1（未调整任何协变量）中 OSA 患者脑肿瘤的风险比（HR）为 1.78（95%置信区间[CI]：1.42-2.21），模型 2（调整收入水平、糖尿病、高血压、血脂异常和 COPD）中为 1.67（95%CI：1.34-2.09）。按性别分层分析，男性 OSA 的优势比（OR）为 1.82（95%CI：1.41-2.33），女性为 1.26（95%CI：0.74-2.03）。年龄≥65 岁组的 OR 为 1.97（95%CI：1.15-3.24），40≤年龄<65 岁组为 1.66（95%CI：1.25-2.17），20≤年龄<40 岁组为 1.41（0.78-2.44）。总之，OSA 可能会增加脑肿瘤的发病率。
