Zersen Kristin M
Department of Clinical Sciences, Colorado State University, Fort Collins, CO, United States.
Front Vet Sci. 2023 Jul 19;10:1083290. doi: 10.3389/fvets.2023.1083290. eCollection 2023.
The primary goals of positive end-expiratory pressure (PEEP) are to restore functional residual capacity through recruitment and prevention of alveolar collapse. Through these mechanisms, PEEP improves arterial oxygenation and may reduce the risk of ventilator-induced lung injury (VILI). Because of the many potential negative effects associated with the use of PEEP, much research has concentrated on determining the optimal PEEP setting. Arterial oxygenation targets and pressure-volume loops have been utilized to set the optimal PEEP for decades. Several other techniques have been suggested, including the use of PEEP tables, compliance, driving pressure (DP), stress index (SI), transpulmonary pressures, imaging, and electrical impedance tomography. Each of these techniques has its own benefits and limitations and there is currently not one technique that is recommended above all others.
呼气末正压（PEEP）的主要目标是通过复张和防止肺泡塌陷来恢复功能残气量。通过这些机制，PEEP可改善动脉氧合，并可能降低呼吸机诱导性肺损伤（VILI）的风险。由于使用PEEP存在许多潜在的负面影响，许多研究都集中在确定最佳PEEP设置上。几十年来，动脉氧合目标和压力-容量环一直被用于设定最佳PEEP。还提出了其他几种技术，包括使用PEEP表、顺应性、驱动压（DP）、应力指数（SI）、跨肺压、成像和电阻抗断层扫描。这些技术中的每一种都有其自身的优点和局限性，目前没有一种技术比其他技术更值得推荐。
