Berg-Hansen Pål, Moen Stine Marit, Klyve Thomas Dahl, Gonzalez Victor, Seeberg Trine Margrethe, Celius Elisabeth Gulowsen, Austeng Andreas, Meyer Frédéric
Department of Neurology, Oslo University Hospital, Oslo, Norway.
MS Center Hakadal, Hakadal, Norway.
Front Neurol. 2023 Jul 19;14:1227374. doi: 10.3389/fneur.2023.1227374. eCollection 2023.
Balance impairment is frequent in people with multiple sclerosis (pwMS) and affects risk of falls and quality of life. By using inertial measurement units (IMUs) on the Single Leg Stance Test (SLS) we aimed to discriminate healthy controls (HC) from pwMS and detect differences in balance endurance and quality. Thirdly, we wanted to test the correlation between instrumented SLS parameters and self-reported measures of gait and balance. Fifty-five pwMS with mild (EDSS<4) and moderate disability (EDSS≥4) and 20 HC performed the SLS with 3 IMUs placed on the feet and sacrum and filled the Twelve Item Multiple Sclerosis Walking Scale (MSWS-12) questionnaire. A linear mixed model was used to compare differences in the automated balance measures. Balance duration was significantly longer in HC compared to pwMS ( < 0.001) and between the two disability groups ( < 0.001). Instrumented measures identified that trunk stability (normalized mediolateral and antero-posterior center of mass stability) had the strongest association with disability (R marginal 0.30, < 0.001) and correlated well with MSWS-12 ( = 0.650, < 0.001). PwMS tended to overestimate own balance compared to measured balance duration. The use of both self-reported and objective assessments from IMUs can secure the follow-up of balance in pwMS.
平衡功能障碍在多发性硬化症患者（pwMS）中很常见，会影响跌倒风险和生活质量。通过在单腿站立测试（SLS）中使用惯性测量单元（IMU），我们旨在区分健康对照者（HC）和pwMS，并检测平衡耐力和质量的差异。第三，我们想测试仪器化的SLS参数与自我报告的步态和平衡测量之间的相关性。55名轻度（扩展残疾状态量表[EDSS]<4）和中度残疾（EDSS≥4）的pwMS患者以及20名HC在双脚和骶骨上放置3个IMU进行了SLS测试，并填写了12项多发性硬化症步行量表（MSWS-12）问卷。使用线性混合模型比较自动平衡测量的差异。与pwMS相比，HC的平衡持续时间明显更长（<0.001），并且在两个残疾组之间也有显著差异（<0.001）。仪器测量表明，躯干稳定性（归一化的内外侧和前后重心稳定性）与残疾的关联最强（R边际值为0.30，<0.001），并且与MSWS-12相关性良好（=0.650，<0.001）。与测量的平衡持续时间相比，pwMS往往高估自己的平衡能力。使用来自IMU的自我报告和客观评估都可以确保对pwMS患者的平衡功能进行随访。
