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正常血小板、Bernard-Soulier血小板和血小板无力症血小板质膜上麦胚凝集素和伴刀豆球蛋白A受体的冷冻断裂细胞化学研究

Freeze-fracture cytochemistry of wheat germ agglutinin and concanavalin A receptors on the plasma membrane of normal, Bernard-Soulier, and thrombasthenic platelets.

作者信息

Chevalier J, Caen J P, Pinto da Silva P

出版信息

Am J Pathol. 1986 Feb;122(2):292-301.

PMID:3753826
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1888117/
Abstract

The authors report here the results of fracture-labeling of wheat germ agglutinin (WGA) and concanavalin A (Con A) receptors on the plasma membranes of normal, Bernard-Soulier, and thrombasthenic platelets. In all cases, virtually all of the label was confined to the exoplasmic half of the membrane. Despite the absence of GP Ib in Bernard-Soulier platelets and the absence or strong reduction of Gp IIb and GP IIIa in thrombasthenic platelets, their plasma membranes were strongly labeled by both Con A and WGA. These results are best accounted for by the presence of other glycoproteins and/or glycolipids at the platelet surface.

摘要

作者在此报告了小麦胚凝集素（WGA）和伴刀豆球蛋白A（Con A）对正常血小板、伯纳德-苏利埃综合征血小板和血小板无力症血小板质膜上受体进行断裂标记的结果。在所有情况下，几乎所有标记都局限于膜的外质部分。尽管伯纳德-苏利埃综合征血小板中缺乏糖蛋白Ib，血小板无力症血小板中缺乏或强烈减少糖蛋白IIb和糖蛋白IIIa，但它们的质膜被Con A和WGA强烈标记。这些结果最好的解释是血小板表面存在其他糖蛋白和/或糖脂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/adb367fb277b/amjpathol00161-0113-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/0f281691d7e5/amjpathol00161-0108-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/836327ce66c6/amjpathol00161-0108-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/b930c0043df9/amjpathol00161-0108-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/f4ade628fb2e/amjpathol00161-0109-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/d9e08e7e3a5e/amjpathol00161-0111-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/fc4ea0e473d1/amjpathol00161-0111-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/7bf4702db24a/amjpathol00161-0112-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/adb367fb277b/amjpathol00161-0113-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/0f281691d7e5/amjpathol00161-0108-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/836327ce66c6/amjpathol00161-0108-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/b930c0043df9/amjpathol00161-0108-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/f4ade628fb2e/amjpathol00161-0109-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/d9e08e7e3a5e/amjpathol00161-0111-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/fc4ea0e473d1/amjpathol00161-0111-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/7bf4702db24a/amjpathol00161-0112-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38be/1888117/adb367fb277b/amjpathol00161-0113-a.jpg

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引用本文的文献

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本文引用的文献

1
Heterogeneity of membrane surface proteins in Glanzmann's thrombasthenia.血小板无力症中膜表面蛋白的异质性。
Blood. 1981 Jan;57(1):174-81.
2
Endocytosis by human platelets: metabolic and freeze-fracture studies.人类血小板的内吞作用：代谢与冷冻蚀刻研究
J Cell Biol. 1981 Dec;91(3 Pt 1):706-15. doi: 10.1083/jcb.91.3.706.
3
Effects of large latex particle uptake of the surface connected canalicular system of blood platelets: a freeze-fracture and cytochemical study.血小板表面连接小管系统摄取大乳胶颗粒的效应：一项冷冻蚀刻和细胞化学研究。
Ultrastruct Pathol. 1981 Jul-Sep;2(3):277-87. doi: 10.3109/01913128109048311.
4
Freeze-fracture cytochemistry: thin sections of cells and tissues after labeling of fractures faces.冷冻断裂细胞化学：骨折面标记后细胞和组织的薄片。
J Histochem Cytochem. 1981 Aug;29(8):917-28. doi: 10.1177/29.8.7276536.
5
Freeze-fracture cytochemistry: replicas of critical point-dried cells and tissues after fracture-label.冷冻断裂细胞化学：临界点干燥的细胞和组织经断裂标记后的复制品。
Science. 1981 Jul 10;213(4504):230-3. doi: 10.1126/science.7244630.
6
Association of membrane and cytoplasmic proteins with the cytoskeleton in blood platelets.血液血小板中膜蛋白和细胞质蛋白与细胞骨架的关联
Biochemistry. 1982 Apr 13;21(8):1713-9. doi: 10.1021/bi00537a002.
7
Glycoproteins of platelet membranes from Glanzmann's thrombasthenia. A comparison with normal using carbohydrate-specific or protein-specific labelling techniques and high-resolution two-dimensional gel electrophoresis.血小板无力症患者血小板膜糖蛋白。采用碳水化合物特异性或蛋白质特异性标记技术及高分辨率二维凝胶电泳与正常人进行比较。
Eur J Biochem. 1981 May 15;116(2):379-88. doi: 10.1111/j.1432-1033.1981.tb05346.x.
8
Studies on platelet glycoproteins in Glanzmann's thrombasthenia using 125I-labelled lectins.使用¹²⁵I标记凝集素对血小板无力症患者血小板糖蛋白的研究。
Br J Haematol. 1980 Sep;46(1):99-107. doi: 10.1111/j.1365-2141.1980.tb05939.x.
9
Freeze-fracture cytochemistry: partition of glycophorin in freeze-fractured human erythrocyte membranes.冷冻蚀刻细胞化学：血型糖蛋白在冷冻蚀刻人红细胞膜中的分布
J Cell Biol. 1982 May;93(2):463-9. doi: 10.1083/jcb.93.2.463.
10
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J Cell Biol. 1981 Nov;91(2 Pt 1):361-72. doi: 10.1083/jcb.91.2.361.