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嗜酸性胃肠炎——一种胃肠道过敏性疾病的表现?第一部分。流行病学与诊断。

Eosinophilic gastroenteritis - a manifestation of an allergic disease in the gastrointestinal tract? Part 1. Epidemiology and diagnosis.

作者信息

Kuźmiński Andrzej, Rosada Tomasz, Przybyszewska Justyna, Ukleja-Sokołowska Natalia, Bartuzi Zbigniew

机构信息

Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

Department of Nutrition and Dietetics, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

出版信息

Prz Gastroenterol. 2023;18(1):43-46. doi: 10.5114/pg.2022.118634. Epub 2022 Aug 9.

DOI:10.5114/pg.2022.118634
PMID:37007757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10050981/
Abstract

Eosinophilic gastroenteritis (EGE) is a relatively rare disease, but it should be considered whenever a patient presents with unexplained gastrointestinal symptoms that cannot be explained by parasitic infection or other gastrointestinal diseases characterized by eosinophilic infiltration. A high coexistence of EGE and allergic diseases has been documented. Diagnosis of EGE is based primarily on clinical, endoscopic, and histopathological findings. Glucocorticosteroids and other immunomodulatory drugs are the mainstay of treatment, but currently the greatest hope lies in biological drugs, which are undergoing intensive research. This disease is troublesome for the patient and significantly reduces the quality of life.

摘要

嗜酸性粒细胞性胃肠炎(EGE)是一种相对罕见的疾病,但每当患者出现无法用寄生虫感染或其他以嗜酸性粒细胞浸润为特征的胃肠道疾病解释的不明原因胃肠道症状时,都应考虑该病。EGE与过敏性疾病的高共存性已有文献记载。EGE的诊断主要基于临床、内镜和组织病理学检查结果。糖皮质激素和其他免疫调节药物是主要治疗手段,但目前最大的希望在于生物药物,相关研究正在紧锣密鼓地进行。这种疾病给患者带来困扰,显著降低生活质量。

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本文引用的文献

1
Eosinophilic Gastritis/Gastroenteritis.嗜酸细胞性胃炎/肠炎。
Curr Gastroenterol Rep. 2021 Jul 30;23(8):13. doi: 10.1007/s11894-021-00809-2.
2
Eosinophilic gastroenteritis: epidemiology, diagnosis, and treatment.嗜酸粒细胞性胃肠炎:流行病学、诊断与治疗。
Curr Opin Allergy Clin Immunol. 2020 Jun;20(3):311-315. doi: 10.1097/ACI.0000000000000635.
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Future therapies for eosinophilic gastrointestinal disorders.嗜酸粒细胞性胃肠道疾病的未来治疗方法。
Ann Allergy Asthma Immunol. 2020 Mar;124(3):219-226. doi: 10.1016/j.anai.2019.11.018. Epub 2019 Nov 26.
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Eosinophilic gastrointestinal diseases - Pathogenesis, diagnosis, and treatment.嗜酸性粒细胞性胃肠道疾病——发病机制、诊断和治疗。
Allergol Int. 2019 Oct;68(4):420-429. doi: 10.1016/j.alit.2019.03.003. Epub 2019 Apr 16.
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Eosinophilic gastroenteritis: Approach to diagnosis and management.嗜酸性胃肠炎:诊断与管理方法
World J Gastrointest Pharmacol Ther. 2016 Nov 6;7(4):513-523. doi: 10.4292/wjgpt.v7.i4.513.
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Eosinophilic gastroenteritis: Clinical profiles and treatment outcomes, a retrospective study of 18 adult patients in a Singapore Tertiary Hospital.嗜酸性胃肠炎:临床特征与治疗结果,一项对新加坡一家三级医院18例成年患者的回顾性研究。
Med J Malaysia. 2015 Aug;70(4):232-7.
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Prevalence of Eosinophilic Gastritis, Gastroenteritis, and Colitis: Estimates From a National Administrative Database.嗜酸性胃炎、胃肠炎和结肠炎的患病率:来自国家行政数据库的估计
J Pediatr Gastroenterol Nutr. 2016 Jan;62(1):36-42. doi: 10.1097/MPG.0000000000000865.
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The number and distribution of eosinophils in the adult human gastrointestinal tract: a study and comparison of racial and environmental factors.成人胃肠道中嗜酸性粒细胞的数量及分布:种族与环境因素的研究及比较
Am J Surg Pathol. 2015 Apr;39(4):521-7. doi: 10.1097/PAS.0000000000000370.
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Eosinophilic gastroenteritis: an unusual type of gastroenteritis.嗜酸性粒细胞性胃肠炎:一种不常见的胃肠炎类型。
World J Gastroenterol. 2013 Aug 21;19(31):5061-6. doi: 10.3748/wjg.v19.i31.5061.
10
Mucosal-type eosinophilic gastroenteritis in Thailand: 12-year retrospective study.泰国黏膜型嗜酸性胃肠炎:一项12年回顾性研究
J Med Assoc Thai. 2013 Feb;96 Suppl 2:S194-202.