Gee M H, Perkowski S Z, Tahamont M V, Flynn J T, Wasserman M A
Am Rev Respir Dis. 1986 Feb;133(2):269-73. doi: 10.1164/arrd.1986.133.2.269.
Intravascular complement activation results in thromboxane (TxA2) production, pulmonary hypertension, hypoxemia, and increased lung vascular permeability. The purpose of this study was to determine the role of TxA2 as a mediator of these responses. Experiments were made in anesthetized sheep subjected to intravenous injections of zymosan-activated plasma (ZAP) every 30 min for 4 h. Sheep were pretreated with dazoxiben, a TxA2 synthetase inhibitor, or SK and F 88046, a TxA2 end-organ antagonist, and the results were compared with those from untreated sheep. Dazoxiben, but not SK and F 88046, inhibited TxA2 release. The hypertensive response averaged 74 +/- 3 cm H2O after each injection of ZAP in untreated sheep. Neither drug altered this response. Pao2 decreased an average of 20 +/- 1 mmHg in untreated sheep, 3 +/- 1 mmHg in dazoxiben-treated sheep, and 11 +/- 1 mmHg in SK and F 88046-treated sheep. Increases in lung lymph flow and lymph protein clearance were unaffected by treatment. TxA2 appears to be an important mediator of hypoxemia during intravascular complement activation.
血管内补体激活会导致血栓素（TxA2）生成、肺动脉高压、低氧血症以及肺血管通透性增加。本研究的目的是确定TxA2作为这些反应介质的作用。实验在麻醉的绵羊身上进行，每隔30分钟静脉注射酵母聚糖激活血浆（ZAP），持续4小时。绵羊预先用TxA2合成酶抑制剂达唑氧苯或TxA2终末器官拮抗剂SK和F 88046进行预处理，并将结果与未处理的绵羊进行比较。达唑氧苯可抑制TxA2释放，但SK和F 88046则不能。未处理的绵羊每次注射ZAP后，高血压反应平均为74±3 cm H2O。两种药物均未改变这种反应。未处理的绵羊动脉血氧分压平均下降20±1 mmHg，达唑氧苯处理的绵羊下降3±1 mmHg，SK和F 88046处理的绵羊下降11±1 mmHg。肺淋巴流量和淋巴蛋白清除率的增加不受治疗影响。TxA2似乎是血管内补体激活期间低氧血症的重要介质。
