Sharma Shweta, Prakash Prithivi R, Narayan Ananthu, Garg Ajay, Wig Naveet
Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Department of Neuro-Radiology, All India Institute of Medical Sciences, New Delhi, India.
Ann Indian Acad Neurol. 2023 May-Jun;26(3):278-280. doi: 10.4103/aian.aian_61_23. Epub 2023 Apr 20.
Acute cerebellar ataxia (ACA) is a self-limited syndrome that is frequently post-infectious, most commonly following infection having an autoimmune mechanism. ACA is the commonest cause of childhood ataxia. We report a 14-year-old male who presented with acute onset wide-based gait and slurring of speech with dysdiadochokinesia, incoordination of voluntary movements, pendular knee jerk, and intentional tremors. He had worsening transaminitis and rising bilirubin during his hospital course and was subsequently found to be hepatitis A virus (HAV) immunoglobulin-M antibody positive. Thus, we report a case of ACA with HAV infection who developed jaundice after three weeks of onset of ataxia, a rarity that has not been reported so far in medical literature.
急性小脑性共济失调（ACA）是一种自限性综合征，常为感染后发病，最常见于具有自身免疫机制的感染之后。ACA是儿童共济失调最常见的病因。我们报告一名14岁男性，其急性起病，表现为宽基底步态、言语含糊不清，伴有轮替运动障碍、随意运动不协调、钟摆样膝反射和意向性震颤。他在住院期间转氨酶升高且胆红素上升，随后被发现甲型肝炎病毒（HAV）免疫球蛋白M抗体呈阳性。因此，我们报告一例ACA合并HAV感染的病例，该患者在共济失调发作三周后出现黄疸，这一罕见情况在医学文献中迄今尚未见报道。
