Sadeghi Ali, Faeli Mohammad, Tajbakhsh Mahmood, Abri Abdolreza, Golpour Monireh
Department of Chemistry, Islamic Azad University, Jouybar Branch, Jouybar, Iran.
Faculty of Chemistry, University of Mazandaran, Babolsar, Iran.
Turk J Chem. 2022 Feb 23;46(4):987-998. doi: 10.55730/1300-0527.3409. eCollection 2022.
In this investigation, a new nanocomposite as a nanocarrier based on functionalized graphene oxide was synthesized by reaction of tetraethylenepentamine and chlorosulfonic acid with functional groups on the surface of GO. The synthesized nanocomposite was characterized by FT-IR, XRD TGA, FE-SEM, EDAX, TEM, and AFM analysis. To explore the potential of nanocomposites in drug delivery, the loading and releases of quercetin as an anticancer drug were investigated. The result displayed that more than 90% of the drug was loaded on the nanocarrier and the release of the drug is depending on the pH of the environment such that the releases of the drug in Gastric and intestinal conditions were up to 50% and 30%, respectively. The analysis of toxicity effect on the normal and cancer cells indicated that the nanocarrier with the drug has potential for cancer cells therapy without cytotoxic effect on normal cells in IC concentration.
在本研究中，通过四乙烯五胺和氯磺酸与氧化石墨烯（GO）表面官能团反应，合成了一种基于功能化氧化石墨烯的新型纳米复合材料作为纳米载体。采用傅里叶变换红外光谱（FT-IR）、X射线衍射（XRD）、热重分析（TGA）、场发射扫描电子显微镜（FE-SEM）、能谱分析（EDAX）、透射电子显微镜（TEM）和原子力显微镜（AFM）分析对合成的纳米复合材料进行了表征。为了探索纳米复合材料在药物递送方面的潜力，研究了抗癌药物槲皮素的负载和释放情况。结果表明，超过90%的药物负载在纳米载体上，药物的释放取决于环境的pH值，在胃部和肠道条件下药物的释放率分别高达50%和30%。对正常细胞和癌细胞的毒性作用分析表明，载有药物的纳米载体在IC浓度下对癌细胞具有治疗潜力，而对正常细胞无细胞毒性作用。
