病毒的独特基因组及其实现的替代策略。
The Unique Genome of the Virus and Alternative Strategies for its Realization.
作者信息
Zhirnov O P
机构信息
The N.F.Gamaleya Research Center of epidemiology and microbiology, The D.I. Ivanovsky Institute of Virology, Moscow, 123098 Russian Federation.
The Russian-German Academy of medico-social and biotechnological sciences; The Innovation Center of Skolkovo, Moscow, 121205 Russian Federation.
出版信息
Acta Naturae. 2023 Apr-Jun;15(2):14-19. doi: 10.32607/actanaturae.11904.
Dedicated to the 130th anniversary of Dmitry Ivanovsky's discovery of the virus kingdom as a new form of biological life. The genome of some RNA-containing viruses comprises ambipolar genes that are arranged in stacks (one above the other) encoding proteins in opposite directions. Ambipolar genes provide a new approach for developing viral diversity when virions possessing an identical genome may differ in its expression scheme (strategy) and have distinct types of progeny virions varying in the genomic RNA polarity and the composition of proteins expressed by positive- or negative-sense genes, the so-called ambipolar virions. So far, this pathway of viral genome expression remains hypothetical and hidden from us, like the dark side of the Moon, and deserves a detailed study.
献给德米特里·伊万诺夫斯基发现病毒界作为一种新的生物生命形式130周年。一些含RNA病毒的基因组包含双极性基因，这些基因以堆叠的方式排列（一个在另一个之上），并以相反的方向编码蛋白质。当具有相同基因组的病毒粒子在其表达模式（策略）上可能不同，并且具有不同类型的子代病毒粒子，这些子代病毒粒子在基因组RNA极性以及由正义或反义基因表达的蛋白质组成上有所不同时，即所谓的双极性病毒粒子，双极性基因提供了一种发展病毒多样性的新方法。到目前为止，这种病毒基因组表达途径仍然是假设性的，对我们来说如同月球的暗面一样隐藏着，值得进行详细研究。
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