National Center for Liver Cancer, Third Affiliated Hospital of Naval Medical University, Shanghai, China.
International Cooperation Laboratory on Signal Transduction, Third Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai, China.
Front Immunol. 2023 Jul 19;14:1204524. doi: 10.3389/fimmu.2023.1204524. eCollection 2023.
Cirrhosis is a progressive and diffuse liver disease characterized by liver tissue fibrosis and impaired liver function. This condition is brought about by several factors, including chronic hepatitis, hepatic steatosis, alcohol abuse, and other immunological injuries. The pathogenesis of liver cirrhosis is a complex process that involves the interaction of various immune cells and cytokines, which work together to create the hepatic homeostasis imbalance in the liver. Some studies have indicated that alterations in the immune microenvironment of liver cirrhosis are closely linked to the development and prognosis of the disease. The noteworthy function of mesenchymal stem cells and their paracrine secretion lies in their ability to promote the production of cytokines, which in turn enhance the self-repairing capabilities of tissues. The objective of this review is to provide a summary of the alterations in liver homeostasis and to discuss intercellular communication within the organ. Recent research on MSCs is yielding a blueprint for cell typing and biomarker immunoregulation. Hopefully, as MSCs researches continue to progress, novel therapeutic approaches will emerge to address cirrhosis.
肝硬化是一种以肝脏组织纤维化和肝功能受损为特征的进行性弥漫性肝脏疾病。这种情况是由多种因素引起的，包括慢性肝炎、肝脂肪变性、酗酒和其他免疫损伤。肝硬化的发病机制是一个复杂的过程，涉及各种免疫细胞和细胞因子的相互作用，共同导致肝脏中肝内稳态失衡。一些研究表明，肝硬化免疫微环境的改变与疾病的发展和预后密切相关。间充质干细胞及其旁分泌分泌的显著功能在于它们能够促进细胞因子的产生，进而增强组织的自我修复能力。本综述的目的是总结肝内稳态的改变，并讨论器官内细胞间的通讯。最近对间充质干细胞的研究为细胞分型和生物标志物免疫调节提供了蓝图。希望随着间充质干细胞研究的不断进展，新的治疗方法将出现以解决肝硬化。
