Child Health Department, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.
Acta Biomed. 2023 Aug 3;94(4):e2023079. doi: 10.23750/abm.v94i4.14142.
Short sleep duration causes many changes in several hormones (leptin, ghrelin, insulin, cortisol, growth hormone) and increases sympathetic activity with elevated levels of catecholamines, which causes an energy imbalance and leads to overweight or obesity and insulin resistance. The present study aimed to analyze the relationship between sleep duration and insulin resistance in obese adolescents with metabolic syndrome.
An observational cross-sectional research design concluded 124 obese adolescents with metabolic syndrome (MetS) aged 13-18 years. Anthropometry, blood pressure, and blood tests were conducted to determine obesity according to CDC 2000. MetS determination based on International Diabetes Federation 2007. Insulin resistance was assessed using HOMA-IR. Sleep duration was determined based on direct interviews with the research subjects. The obtained data were analyzed using the Spearman correlation test, Chi-Square, Mann-Whitney, and T-test (significant at P <0.05).
The subjects were dominated by male adolescents 67.5%. There was a strong relationship between age and sleep duration (p = 0.035). Subjects were divided into two age groups based on sleep duration: those with < 8 hours and > 8 hours of sleep. There was a significant difference in fasting insulin levels and HOMA IR value between the two groups, higher in the subjects with < 8 hours of sleep than the subjects with > 8 hours of sleep. Sleep duration and HOMA-IR values as a marker of insulin resistance had a significant negative correlation (rs= -0.581; P <0.001) and insulin levels (rs=-0.565, P <0.001).
Sleep duration has a robust negative correlation with the HOMA-IR value, which is a parameter of insulin resistance. (www.actabiomedica.it).
睡眠时间短会导致许多激素（瘦素、胃饥饿素、胰岛素、皮质醇、生长激素）发生变化，并增加儿茶酚胺水平，从而提高交感神经活动，导致能量失衡，导致超重或肥胖和胰岛素抵抗。本研究旨在分析代谢综合征肥胖青少年睡眠时间与胰岛素抵抗的关系。
采用观察性横断面研究设计，纳入 124 名年龄在 13-18 岁的代谢综合征（MetS）肥胖青少年。根据美国疾病控制与预防中心（CDC）2000 年的标准进行人体测量、血压和血液检查，以确定肥胖。根据 2007 年国际糖尿病联合会（IDF）确定 MetS。使用 HOMA-IR 评估胰岛素抵抗。根据研究对象的直接访谈确定睡眠时间。使用 Spearman 相关检验、卡方检验、Mann-Whitney 和 T 检验（P<0.05 为差异有统计学意义）对获得的数据进行分析。
研究对象以男性青少年为主，占 67.5%。年龄与睡眠时间之间存在很强的相关性（p=0.035）。根据睡眠时间将研究对象分为两组：睡眠时间<8 小时和>8 小时。两组之间的空腹胰岛素水平和 HOMA IR 值存在显著差异，睡眠时间<8 小时的受试者高于睡眠时间>8 小时的受试者。睡眠时间和 HOMA-IR 值作为胰岛素抵抗的标志物呈显著负相关（rs=-0.581；P<0.001）和胰岛素水平（rs=-0.565，P<0.001）。
睡眠时间与 HOMA-IR 值呈显著负相关，HOMA-IR 值是胰岛素抵抗的参数。（www.actabiomedica.it）。
