CICS-UBI - Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, 6200-506 Covilhã, Portugal.
Departamento de Química, Universidade da Beira Interior, 6201-001 Covilhã, Portugal.
Biomater Sci. 2023 Sep 12;11(18):6082-6108. doi: 10.1039/d3bm00845b.
Progress in the nanotechnology field has led to the development of a new class of materials capable of producing a temperature increase triggered by near infrared light. These photothermal nanostructures have been extensively explored in the ablation of cancer cells. Nevertheless, the available data in the literature have exposed that systemically administered nanomaterials have a poor tumor-homing capacity, hindering their full therapeutic potential. This paradigm shift has propelled the development of new injectable hydrogels for the local delivery of nanomaterials aimed at cancer photothermal therapy. These hydrogels can be assembled at the tumor site after injection ( forming) or can undergo a gel-sol-gel transition during injection (shear-thinning/self-healing). Besides incorporating photothermal nanostructures, these injectable hydrogels can also incorporate or be combined with other agents, paving the way for an improved therapeutic outcome. This review analyses the application of injectable hydrogels for the local delivery of nanomaterials aimed at cancer photothermal therapy as well as their combination with photodynamic-, chemo-, immuno- and radio-therapies.
纳米技术领域的进展催生了一类新型材料的发展，这类材料能够在近红外光的触发下产生温升。这些光热纳米结构在癌细胞消融中得到了广泛的探索。然而，文献中的现有数据表明，系统给予的纳米材料对肿瘤的归巢能力较差，限制了它们的全部治疗潜力。这一范式转变推动了新型可注射水凝胶的发展，用于局部递送电镜材料以实现癌症光热治疗。这些水凝胶在注射后可以在肿瘤部位组装（形成），也可以在注射过程中经历凝胶-溶胶-凝胶转变（剪切稀化/自修复）。除了包含光热纳米结构外，这些可注射水凝胶还可以包含或与其他药物联合使用，为改善治疗效果铺平道路。本文综述了可注射水凝胶在局部递送电镜材料以实现癌症光热治疗中的应用，以及它们与光动力、化疗、免疫和放射治疗的联合应用。
