Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
Department of Neurology, University of California, Irvine, California, USA.
Behav Sleep Med. 2023 Sep 3;21(5):620-632. doi: 10.1080/15402002.2022.2148668. Epub 2022 Nov 23.
To examine sex-specific associations of sleep duration and napping self-reported at mean age of 69 years (range: 53-81) with risk of incident dementia 24 years later at age 90 +.
Analytic sample included individuals from a population-based study who reported sleep and napping once in the 1980s and 24 years later (range: 16-38) joined and were evaluated in-person. Those without dementia at baseline of were prospectively followed. Hazard ratios [HR] and 95% confidence intervals [CI] of dementia risk were estimated by Cox regression.
Of 574 participants 71% were women, mean age at start of dementia follow-up with was 93 years (range: 90-102). After 3.3 years (range: 0.4-13.8) of follow-up 47% developed dementia. Higher risk of dementia at age 90+ was seen in women with <6 hours of self-reported sleep per night (adjusted HR = 2.00; 95% CI = 1.15-3.50; = .01) compared with 8 hours. Lower risk of dementia at 90+ was seen in men with short-to-moderate (<60 minutes) self-reported naps compared with no naps (HR = 0.33; 95% CI = 0.18-0.63; < .01).
Sleep and nap 24 years earlier are important risk factors for dementia after age 90.
研究 69 岁（53-81 岁）时报告的睡眠时间和午睡与 24 年后 90 岁以上新发痴呆的风险之间的性别特异性关联。
分析样本包括来自一项基于人群的研究的个体，他们在 20 世纪 80 年代报告过一次睡眠和午睡，24 年后（范围：16-38 岁）加入并进行了面对面评估。基线时无痴呆的人被前瞻性随访。痴呆风险的风险比（HR）和 95%置信区间（CI）通过 Cox 回归估计。
574 名参与者中 71%为女性，痴呆随访开始时的平均年龄为 93 岁（范围：90-102）。随访 3.3 年后（范围：0.4-13.8），47%的人发生痴呆。与每晚报告 8 小时相比，每晚报告睡眠不足 6 小时的女性痴呆风险更高（调整后的 HR=2.00；95%CI=1.15-3.50；=0.01）。与没有午睡相比，报告短至中度（<60 分钟）午睡的男性痴呆风险较低（HR=0.33；95%CI=0.18-0.63；<0.01）。
24 年前的睡眠和午睡是 90 岁以上痴呆的重要危险因素。
