人雌激素受体cDNA：序列、表达及与v-erb-A的同源性
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.
作者信息
Green S, Walter P, Kumar V, Krust A, Bornert J M, Argos P, Chambon P
出版信息
Nature. 1986;320(6058):134-9. doi: 10.1038/320134a0.
DOI:10.1038/320134a0
PMID:3754034
Abstract
We have cloned and sequenced the complete complementary DNA of the oestrogen receptor (ER) present in the breast cancer cell line MCF-7. The expression of the ER cDNA in HeLa cells produces a protein that has the same relative molecular mass and binds oestradiol with the same affinity as the MCF-7 ER. There is extensive homology between the ER and the erb-A protein of the oncogenic avian erythroblastosis virus.
摘要
我们已经克隆并测序了乳腺癌细胞系MCF-7中存在的雌激素受体（ER）的完整互补DNA。ER cDNA在HeLa细胞中的表达产生了一种蛋白质，其相对分子质量与MCF-7 ER相同，并且与雌二醇结合的亲和力也相同。ER与致癌性禽成红细胞增多症病毒的erb-A蛋白之间存在广泛的同源性。
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