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用于炎症性疾病的选择性和有效治疗的活性氧响应性聚合物前药纳米粒子。

Reactive Oxygen Species-Responsive Polymeric Prodrug Nanoparticles for Selective and Effective Treatment of Inflammatory Diseases.

机构信息

State Key Laboratory of Pharmaceutical Biotechnology & Dr. Li Dak-Sum Research Centre & Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Department of Minimally Invasive Interventional Radiology, State Key Laboratory of Respiratory Disease, School of Biomedical Engineering & The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China.

出版信息

Adv Healthc Mater. 2023 Nov;12(29):e2301394. doi: 10.1002/adhm.202301394. Epub 2023 Aug 17.

DOI:10.1002/adhm.202301394
PMID:37540810
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11468797/
Abstract

It is challenging to manage inflammatory diseases using traditional anti-inflammatory drugs due to their limited efficacy and systemic side effects, which are a result of their lack of selectivity, poor stability, and low solubility. Herein, it reports the development of a novel nanoparticle system, called ROS-CA-NPs, which is formed using polymer-cinnamaldehyde (CA) conjugates and is responsive to reactive oxygen species (ROS). ROS-CA-NPs exhibit excellent drug stability, tissue selectivity, and controlled drug release upon oxidative stress activation. Using mouse models of chronic rheumatoid arthritis and acute ulcerative colitis, this study demonstrates that the systemic administration of ROS-CA-NPs results in their accumulation at inflamed lesions and leads to greater therapeutic efficacy compared to traditional drugs. Furthermore, ROS-CA-NPs present excellent biocompatibility. The findings suggest that ROS-CA-NPs have the potential to be developed as safe and effective nanotherapeutic agents for a broad range of inflammatory diseases.

摘要

由于传统抗炎药物的疗效有限且存在全身性副作用，因此在治疗炎症性疾病方面具有挑战性，这是由于它们缺乏选择性、稳定性差和溶解度低所致。在此，报告了一种新型纳米颗粒系统的开发，称为 ROS-CA-NPs，它是由聚合物-肉桂醛 (CA) 缀合物形成的，并对活性氧 (ROS) 有响应。ROS-CA-NPs 在氧化应激激活时表现出优异的药物稳定性、组织选择性和控制药物释放。使用慢性类风湿关节炎和急性溃疡性结肠炎的小鼠模型，本研究表明，ROS-CA-NPs 的全身给药导致其在炎症病变部位积累，并与传统药物相比具有更好的治疗效果。此外，ROS-CA-NPs 具有出色的生物相容性。这些发现表明，ROS-CA-NPs 有可能被开发为用于广泛炎症性疾病的安全有效的纳米治疗剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a3/11468797/b87fd716a7c0/ADHM-12-2301394-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a3/11468797/c8dd62086da2/ADHM-12-2301394-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a3/11468797/b87fd716a7c0/ADHM-12-2301394-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a3/11468797/a3016202eb4b/ADHM-12-2301394-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a3/11468797/d4f40dcc8846/ADHM-12-2301394-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a3/11468797/5504caef6fdd/ADHM-12-2301394-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a3/11468797/8af40350e0c0/ADHM-12-2301394-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58a3/11468797/b87fd716a7c0/ADHM-12-2301394-g008.jpg

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