Lampard D G, Brown W A, Cass N M, Ng K C
Anaesth Intensive Care. 1986 Feb;14(1):7-11. doi: 10.1177/0310057X8601400103.
Paralysis was maintained in sheep by computer-controlled infusion of atracurium, using the integrated electromyogram as a measure of neuromuscular transmission. A number of experiments were conducted to ascertain the average infusion rate required to achieve a given level of paralysis for one hour. Each experiment yielded a point on a plot of paralysis versus infusion rate. A dose-response curve based upon a simple model of drug receptor interaction at the neuromuscular junction was fitted to the experimental points by least squares and is able to provide a useful explanation of clinically observed behaviour. The recovery time was also measured in each experiment and plotted against both prior level of paralysis and prior average infusion rate.
通过计算机控制输注阿曲库铵使绵羊维持麻痹状态，使用整合肌电图作为神经肌肉传递的指标。进行了多项实验以确定维持一小时特定麻痹水平所需的平均输注速率。每个实验在麻痹程度与输注速率的关系图上得出一个点。基于神经肌肉接头处药物受体相互作用的简单模型的剂量反应曲线通过最小二乘法拟合实验点，并且能够为临床观察到的行为提供有用的解释。在每个实验中还测量了恢复时间，并将其与先前的麻痹水平和先前的平均输注速率进行绘图。
