Bradlow H S, Uys P C, Rametti L B
J Biomed Eng. 1986 Jan;8(1):72-5. doi: 10.1016/0141-5425(86)90034-8.
We described recently a microcomputer system capable of controlling muscle relaxation during surgical procedures; the system was tested and evaluated in 42 clinical trials involving the use of the muscle relaxant, d-tubocurarine. The advent of new non-depolarizing neuromuscular blocking drugs with significant clinical advantages makes it essential that any automatic control system for muscle relaxation can also be used with such drugs, and benefit from their improved properties. This paper describes a series of 22 clinical trials in which our controller was used successfully to control muscle relaxation using atracurium. We also investigated an alternative control strategy, taking advantage of the rapid elimination of atracurium from the body.
我们最近描述了一种能够在外科手术过程中控制肌肉松弛的微型计算机系统；该系统在42项涉及使用肌肉松弛剂d-筒箭毒碱的临床试验中进行了测试和评估。具有显著临床优势的新型非去极化神经肌肉阻滞剂的出现，使得任何肌肉松弛自动控制系统也能用于此类药物，并受益于其改进的特性变得至关重要。本文描述了一系列22项临床试验，在这些试验中，我们的控制器成功地用于使用阿曲库铵控制肌肉松弛。我们还研究了一种替代控制策略，利用阿曲库铵从体内快速消除的特点。
