Division of Nephrology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.
Division of Nephrology, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.
Biomed Pharmacother. 2023 Sep;165:115269. doi: 10.1016/j.biopha.2023.115269. Epub 2023 Aug 2.
Septic acute kidney injury (SAKI) is one of the most common and life-threatening complications of sepsis. Patients with SAKI have increased mortality. However, the underlying pathogenesis is unclear, and the treatment targeting SAKI is unsatisfactory. Thus, identifying optimal biomarkers for SAKI diagnosis and treatment is an urgent requisite. Accumulating evidence indicates that noncoding RNAs (ncRNAs) are involved in the occurrence and progression of SAKI. In the present review, we summarized the studies of ncRNAs in SAKI, including microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs). The ncRNAs are divided into protective and damage factors according to their role in SAKI, and their expression patterns, functions, and molecular mechanisms were elaborated. Next, we proposed that ncRNAs have the potential to be diagnostic and prognostic biomarkers for SAKI and as new therapeutic targets. This review aimed to provide a comprehensive overview of ncRNAs in SKAI and explored the clinical value of ncRNAs as ideal biomarkers of SAKI.
脓毒症急性肾损伤（SAKI）是脓毒症最常见且最具威胁生命的并发症之一。患有 SAKI 的患者死亡率增加。然而，其潜在的发病机制尚不清楚，针对 SAKI 的治疗也不尽人意。因此，确定用于 SAKI 诊断和治疗的最佳生物标志物是当务之急。越来越多的证据表明，非编码 RNA（ncRNA）参与了 SAKI 的发生和发展。在本综述中，我们总结了 ncRNA 在 SAKI 中的研究，包括 microRNAs（miRNAs）、长链非编码 RNA（lncRNA）和环状 RNA（circRNA）。根据它们在 SAKI 中的作用，ncRNA 分为保护因子和损伤因子，并详细阐述了它们的表达模式、功能和分子机制。接下来，我们提出 ncRNA 有可能成为 SAKI 的诊断和预后生物标志物，并作为新的治疗靶点。本综述旨在全面概述 SAKI 中的 ncRNA，并探讨 ncRNA 作为 SAKI 理想生物标志物的临床价值。
