Wang Peng, Zhou Miao-Miao, Nie Jing
Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Guangzhou 510515, China.
Sheng Li Xue Bao. 2022 Feb 25;74(1):39-46.
Acute kidney injury (AKI) is a common clinical syndrome and an independent risk factor of chronic kidney disease and end-stage renal failure. At present, the treatments of AKI are still very limited and the morbidity and mortality of AKI are rising. Non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs and circular RNAs (circRNAs), are RNAs that are transcribed from the genome, but not translated into proteins. It has been widely reported that ncRNA is involved in AKI caused by ischemia reperfusion injury (IRI), drugs and sepsis through different molecular biological mechanisms, such as apoptosis and oxidative stress response. Therefore, ncRNAs are expected to become a new target for clinical prevention and treatment of AKI and a new biomarker for early warning of the occurrence and prognosis of AKI. Here, the role and mechanism of ncRNA in AKI and the research progress of ncRNA as biomarkers are reviewed.
急性肾损伤（AKI）是一种常见的临床综合征，也是慢性肾脏病和终末期肾衰竭的独立危险因素。目前，AKI的治疗方法仍然非常有限，且AKI的发病率和死亡率正在上升。非编码RNA（ncRNAs），包括微小RNA、长链非编码RNA和环状RNA（circRNAs），是从基因组转录而来但不翻译成蛋白质的RNA。已有广泛报道称，ncRNA通过不同的分子生物学机制，如细胞凋亡和氧化应激反应，参与了由缺血再灌注损伤（IRI）、药物和脓毒症引起的AKI。因此，ncRNAs有望成为临床预防和治疗AKI的新靶点以及AKI发生和预后早期预警的新生物标志物。在此，对ncRNA在AKI中的作用和机制以及ncRNA作为生物标志物的研究进展进行综述。
