Sun Mengqi, Li Tianyu, Sun Qinglin, Ren Xiaoke, Sun Zhiwei, Duan Junchao
Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China.
Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China.
Sci Total Environ. 2023 Dec 10;903:166010. doi: 10.1016/j.scitotenv.2023.166010. Epub 2023 Aug 3.
This review aimed to establish a holistic perspective of long-term PM exposure and cardiometabolic diseases, identify long-term PM-related cardiovascular and metabolic risk factors, and provide practical significance to preventative measures.
A combination of computer and manual retrieval was used to search for keywords in PubMed (2903 records), Embase (2791 records), Web of Science (5488 records) and Cochrane Library (163 records). Finally, a total of 82 articles were considered in this meta-analysis. Stata 13.0 was accustomed to inspecting the studies' heterogeneity and calculating the combined effect value (RR) by selecting the matching models. The subgroup analysis, sensitivity analysis and publication bias tests were also performed.
Meta-analysis figured an association between PM and cardiometabolic diseases. PM (per 10 μg/m increase) boosted the risk of hypertension (RR = 1.14, 95 % CI: 1.09-1.19), coronary heart disease (CHD) (RR = 1.21, 95 % CI: 1.08-1.35), diabetes (RR = 1.16, 95 % CI: 1.11-1.21) and stroke (including ischemic stroke and hemorrhagic stroke). PM (per 10 μg/m increase) elevated the incidence of hypertension (RR = 1.11, 95 % CI: 1.07-1.16) and diabetes (RR = 1.26, 95 % CI: 1.08-1.47). PM (per 10 μg/m increase) exposure increased the risk of total dyslipidemia, yielding the RR of 1.10 (95 % CI: 1.01-1.18). Furthermore, the elderly, overweight and higher background pollutant level were potentially susceptible to related diseases.
There was a virtual connection between long-term exposure to PM and cardiometabolic diseases. PM or PM (per 10 μg/m) increased the risk of hypertension, CHD, diabetes, stroke and dyslipidemia, causing cardiovascular "multimorbidity" in high-risk populations.
本综述旨在建立长期暴露于细颗粒物（PM）与心脏代谢疾病之间的整体观点，确定与长期PM相关的心血管和代谢危险因素，并为预防措施提供实际意义。
采用计算机检索和手工检索相结合的方法，在PubMed（2903条记录）、Embase（2791条记录）、Web of Science（5488条记录）和Cochrane图书馆（163条记录）中搜索关键词。最后，本荟萃分析共纳入82篇文章。使用Stata 13.0检查研究的异质性，并通过选择匹配模型计算合并效应值（RR）。还进行了亚组分析、敏感性分析和发表偏倚检验。
荟萃分析表明PM与心脏代谢疾病之间存在关联。PM每增加10μg/m³，高血压风险增加（RR = 1.14，95%CI：1.09 - 1.19）、冠心病（CHD）风险增加（RR = 1.21，95%CI：1.08 - 1.35）、糖尿病风险增加（RR = 1.16，95%CI：1.11 - 1.21）以及中风（包括缺血性中风和出血性中风）风险增加。PM每增加10μg/m³，高血压发病率增加（RR = 1.11，95%CI：1.07 - 1.16），糖尿病发病率增加（RR = 1.26，95%CI：1.08 - 1.47）。PM每增加暴露10μg/m³，总血脂异常风险增加，RR为1.10（95%CI：1.01 - 1.18）。此外，老年人、超重者以及背景污染物水平较高者更容易患相关疾病。
长期暴露于PM与心脏代谢疾病之间存在实质联系。PM或每增加10μg/m³的PM会增加高血压、冠心病、糖尿病、中风和血脂异常风险，在高危人群中导致心血管“多病共患”。
