Wang Bo, Yang Lingling, Ma Ting, He Shulan, Li Jiangping, Sun Xian
School of Public Health, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
Key Laboratory of Environmental Factors and Chronic Disease Control, No.1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, China.
Sci Rep. 2025 Jan 15;15(1):2089. doi: 10.1038/s41598-024-83607-w.
Lifestyle factors and ambient air pollution are linked to dementia and CMDs, yet few studies have investigated their impact on dementia risk in CMDs patients at the same time. The Cox proportional hazards model was used to evaluate the influence of lifestyle and ambient air pollution on the dementia risk of the CMDs population among 438,681 participants in the UK Biobank. It is found that the risk of developing mild cognitive impairment and dementia in the population seems to increase with the increase in the number of CMDs. There appears to be a statistically significant association between high levels of ambient air pollution, unhealthy lifestyles, and a higher risk of developing mild cognitive impairment and dementia in the CMDs population. It is found that a healthy lifestyle may have an effect modifier role in the association between ambient air pollution and the risk of mild cognitive impairment and the development of dementia in patients with CMDs. Therefore, maybe people with CMDs can lessen the impact of ambient air pollution on their risk of developing mild cognitive impairment and dementia by improving their lifestyle.
生活方式因素和环境空气污染与痴呆症和慢性身心疾病有关，但很少有研究同时调查它们对慢性身心疾病患者痴呆风险的影响。采用Cox比例风险模型评估生活方式和环境空气污染对英国生物银行438,681名参与者中慢性身心疾病人群痴呆风险的影响。研究发现，慢性身心疾病患者群体中发生轻度认知障碍和痴呆症的风险似乎随着慢性身心疾病数量的增加而增加。环境空气污染水平高、不健康的生活方式与慢性身心疾病人群发生轻度认知障碍和痴呆症的较高风险之间似乎存在统计学上的显著关联。研究发现，健康的生活方式可能在环境空气污染与慢性身心疾病患者轻度认知障碍风险和痴呆症发展之间的关联中起到效应修饰作用。因此，也许慢性身心疾病患者可以通过改善生活方式来减轻环境空气污染对其发生轻度认知障碍和痴呆症风险的影响。
