Irwig Michael S, Sanz Jessika, Lin Deborah, Tan Nicholas, Dommasch Erica
Harvard Medical School, Boston, MA, USA.
Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Int J Impot Res. 2025 Jun;37(6):451-453. doi: 10.1038/s41443-023-00750-0. Epub 2023 Aug 4.
Finasteride may cause low libido and erectile dysfunction and the product label of finasteride also includes post-marketing reactions of sexual dysfunction that continued after discontinuation of treatment, as well as male infertility and depression. The aim of this study was to evaluate the beliefs and counseling practices among dermatologists regarding adverse effects of finasteride. Anonymous paper surveys were personally distributed to 122 attendees at two annual major dermatology meetings. The participation rate was 82% with 47% women and 77% residents of the United States. 51% of respondents believed that finasteride could cause sexual side effects and 18% believed that it could cause persistent sexual side effects. Fewer than a quarter believed that finasteride could cause depression or lower sperm counts. When initiating finasteride, 69% of respondents counseled at least half of their patients about potential sexual side effects with 52% for persistent sexual side effects and 30% for depression. This study identifies the need for greater awareness of the potential adverse effects of finasteride and identifies opportunities for improvement in counseling practices that reflect finasteride's product labeling.
非那雄胺可能会导致性欲减退和勃起功能障碍，非那雄胺的产品标签还包括治疗停药后仍持续存在的性功能障碍的上市后反应，以及男性不育和抑郁。本研究的目的是评估皮肤科医生对非那雄胺不良反应的认知和咨询实践。在两次年度主要皮肤科会议上，向122名与会者亲自发放了匿名纸质调查问卷。参与率为82%，其中47%为女性，77%为美国居民。51%的受访者认为非那雄胺会引起性副作用，18%的受访者认为它会导致持续性性副作用。不到四分之一的人认为非那雄胺会导致抑郁或精子数量减少。在开始使用非那雄胺时，69%的受访者会向至少一半的患者咨询潜在的性副作用，52%的受访者会咨询持续性性副作用，30%的受访者会咨询抑郁问题。本研究指出需要提高对非那雄胺潜在不良反应的认识，并确定改进咨询实践的机会，使其符合非那雄胺的产品标签。
