Gupta Jitendra, Suliman Muath, Ali Rida, Margiana Ria, Hjazi Ahmed, Alsaab Hashem O, Qasim Maytham T, Hussien Beneen M, Ahmed Muhja
Institute of Pharmaceutical Research, GLA University, Mathura 281406, U. P., India.
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Pathol Res Pract. 2023 Aug;248:154701. doi: 10.1016/j.prp.2023.154701. Epub 2023 Jul 20.
Understanding the function and mode of operation of microRNAs (miRNAs) in cancer is of growing interest. The short non-coding RNAs known as miRNAs, which target mRNA in multicellular organisms, are described as controlling essential cellular processes. The miR-181 family and miR-633 are well-known miRNAs that play a key role in the development and metastasis of tumor cells. They may facilitate either tumor-suppressive or oncogenic function in malignant cells, according to mounting evidence. Metastatic cells that are closely linked to cancer cell migration, invasion, and angiogenesis can be identified by abnormal levels of miR-181 and miR-633. Numerous studies have demonstrated their capacity to control drug resistance, cell growth, apoptosis, and the epithelial-mesenchymal transition (EMT) and metastasis process. Interestingly, the levels of miR-181 and miR-633 and their potential target genes in the basic cellular process can vary depending on the type of cancer cells and their gene expression profile. Such miRNAs' interactions with other non-coding RNAs such as long non-coding RNAs and circular RNAs can influence tumor behaviors. Herein, we concentrated on the multifaceted roles of miR-181 and miR-633 and potential targets in human tumorigenesis, ranging from cell growth and metastasis to drug resistance.
了解微小RNA（miRNA）在癌症中的功能和作用模式越来越受到关注。被称为miRNA的短链非编码RNA可靶向多细胞生物中的mRNA，被认为控制着重要的细胞过程。miR-181家族和miR-633是众所周知的miRNA，它们在肿瘤细胞的发展和转移中起关键作用。越来越多的证据表明，它们在恶性细胞中可能促进肿瘤抑制或致癌功能。与癌细胞迁移、侵袭和血管生成密切相关的转移细胞可通过miR-181和miR-633的异常水平来识别。大量研究表明它们具有控制耐药性、细胞生长、凋亡以及上皮-间质转化（EMT）和转移过程的能力。有趣的是，在基本细胞过程中，miR-181和miR-633的水平及其潜在靶基因可能因癌细胞类型及其基因表达谱而异。此类miRNA与其他非编码RNA（如长链非编码RNA和环状RNA）的相互作用可影响肿瘤行为。在此，我们集中探讨了miR-181和miR-633在人类肿瘤发生中的多方面作用以及从细胞生长、转移到耐药性的潜在靶点。
