Kornegay R W, Giddens W E, Morton W R, Knitter G H
Lab Anim Sci. 1986 Feb;36(1):45-7.
An apparently healthy cynomolgus monkey (Macaca fascicularis) died 2 hours after routine inhalation anesthesia and implantation of a femoral catheter. Gross necropsy findings included patchy raised areas of severe pulmonary hemorrhage and consolidation. Filarioid nematodes (Edesonfilaria malayensis) were located in pulmonary blood vessels and in numerous 0.1-2 cm fibrous cysts on the pleural surfaces of the lungs, pericardium, diaphragm, retroperitoneum, and in the urinary bladder wall. Microscopic lesions included verminous vasculitis, pulmonary infarcts and pneumonia. Many of the nematodes were more necrotic than the surrounding host tissue. During quarantine, 17 days before surgery, the monkey had been given a single dose of ivermectin (200 micrograms/Kg, intramuscular) as an anthelminthic for gastrointestinal nematodes. It is postulated that many of the filarioid nematodes were killed by this treatment. These parasitic emboli caused pulmonary infarction and the severe inflammatory reaction. The resulting pulmonary disease compromised pulmonary function and contributed to death after anesthesia. This complication should be considered if monkeys possibly harboring filarioid nematodes are treated with ivermectin.
一只外表健康的食蟹猴（猕猴）在常规吸入麻醉和植入股静脉导管后2小时死亡。大体尸检结果包括散在的严重肺出血和实变的隆起区域。丝状线虫（马来埃氏丝虫）位于肺血管以及肺、心包、膈肌、腹膜后和膀胱壁胸膜表面众多0.1 - 2厘米的纤维囊肿中。微观病变包括蠕虫性血管炎、肺梗死和肺炎。许多线虫比周围的宿主组织坏死更严重。在隔离期间，手术前17天，这只猴子曾接受单剂量伊维菌素（200微克/千克，肌肉注射）作为胃肠道线虫的驱虫药。据推测，许多丝状线虫被这种治疗杀死。这些寄生栓子导致了肺梗死和严重的炎症反应。由此产生的肺部疾病损害了肺功能，并导致麻醉后死亡。如果可能携带丝状线虫的猴子用伊维菌素治疗，应考虑这种并发症。
