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刺激蓝斑核产生镇痛作用的药理学研究。

A pharmacologic study of analgesia produced by stimulation of the nucleus locus coeruleus.

作者信息

Margalit D, Segal M

出版信息

Psychopharmacology (Berl). 1979 Apr 11;62(2):169-73. doi: 10.1007/BF00427132.

DOI:10.1007/BF00427132
PMID:37543
Abstract

Pharmacologic studies of analgesia produced by stimulation of the nucleus locus coeruleus (LC) were conducted using the rat hot-plate test. A correlation between self-stimulation and analgesia produced by stimulation of LC was found. Analgesia produced by LC stimulation was attenuated by naloxone, a morphine antagonist, cyproheptidine, a serotonin antagonist, and WB-4101, an alpha-adrenergic antagonist. The analgesia was absent in 6-OHDA-treated rats. Catecholamine synthesis inhibition by a combination of reserpine and AMT or more specific inhibition of noradrenaline synthesis by DDC elevated latency to paw lick and yet did not affect stimulation-produced analgesia. It is suggested that morphinergic, serotonergic, and alpha-adrenergic mechanisms mediate LC stimulation produced analgesia.

摘要

利用大鼠热板试验对刺激蓝斑核（LC）产生的镇痛作用进行了药理学研究。发现自我刺激与刺激LC产生的镇痛之间存在相关性。LC刺激产生的镇痛作用被纳洛酮（一种吗啡拮抗剂）、赛庚啶（一种5-羟色胺拮抗剂）和WB-4101（一种α-肾上腺素能拮抗剂）减弱。在经6-羟基多巴胺处理的大鼠中未出现镇痛作用。利血平和AMT联合使用对儿茶酚胺合成的抑制作用，或DDC对去甲肾上腺素合成的更特异性抑制作用，均延长了舔爪潜伏期，但并未影响刺激产生的镇痛作用。提示吗啡能、5-羟色胺能和α-肾上腺素能机制介导了LC刺激产生的镇痛作用。

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