Shah V C, Vyas R C, Adhvaryu S G
Neoplasma. 1986;33(1):33-7.
1-(2-Chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (Me-CCNU) was tested for its in vitro effects on sister chromatid exchanges (SCE), cellular kinetics and chromosome aberrations in CHO cells. There was a relationship between the inhibitory activity of the drug and the cytogenetic damage, which was dose dependent. Increase in SCE values were highly significant (p less than 0.001) for all the four concentrations used. It also delayed the cell cycle progression. Inhibition of DNA synthesis results in increased frequency of chromosomal aberrations, which was highly significant for the higher concentrations, i.e. 5 micrograms and 10 micrograms Me-CCNU/ml.
1-（2-氯乙基）-3-（反式-4-甲基环己基）-1-亚硝基脲（甲基洛莫司汀，Me-CCNU）针对其对中国仓鼠卵巢（CHO）细胞姐妹染色单体交换（SCE）、细胞动力学及染色体畸变的体外效应进行了测试。该药物的抑制活性与细胞遗传学损伤之间存在剂量依赖性关系。在所使用的全部四种浓度下，SCE值的增加均极为显著（p小于0.001）。它还使细胞周期进程延迟。DNA合成的抑制导致染色体畸变频率增加，对于较高浓度即5微克/毫升和10微克/毫升的甲基洛莫司汀而言，这种增加极为显著。
