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某些烷基芳基亚硝基脲在中国仓鼠V79-E细胞中的致断裂性及畸变动力学

Clastogenicity and aberration kinetics of some alkylarylnitrosoureas in Chinese hamster V79-E cells.

作者信息

Thust R, Mendel J, Schwarz H, Warzok R

出版信息

IARC Sci Publ. 1980(31):797-802.

PMID:7228300
Abstract

Six alkylarylnitrosoureas were checked for induction of chromosome aberrations and SCEs in Chinese hamster V79-E cells and compared with MNU, ENU and nitrosocarbaryl. All agents show a DNA-damaging activity. Studies of the dependence of aberration frequency on recovery time revealed drastic differences within this group of closely related substances.

摘要

检测了六种烷基芳基亚硝基脲在中国仓鼠V79-E细胞中诱导染色体畸变和姐妹染色单体交换（SCEs）的情况，并与N-甲基-N-亚硝基脲（MNU）、N-乙基-N-亚硝基脲（ENU）和亚硝基甲萘威进行了比较。所有试剂均显示出DNA损伤活性。对畸变频率与恢复时间依赖性的研究揭示了这组密切相关物质之间的巨大差异。

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