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[体内和体外染色体畸变及姐妹染色单体交换频率与环磷酰胺诱变暴露剂量的比值]

[Ratio of the frequency of chromosome aberrations and sister chromatid exchanges to the dose of the mutagenic exposure to cyclophosphamide in vivo and in vitro].

作者信息

Stukalov S V, Kuzin S M, Viktorov V V

出版信息

Biull Eksp Biol Med. 1986 Apr;101(4):461-3.

PMID:3697494
Abstract

Cyclophosphamide (CP) and its metabolites were used to compare the rate of chromosomal aberrations (CA) and sister chromatid exchange (SCE) in the rabbit lymphocytes in vivo and in vitro. The dose-dependent increase of cytogenetic effects rate appeared to be of linear and exponential dependence for SCE and CA, respectively, both in vivo and in vitro. The regression equation coefficients coincided in in vivo and in vitro experiments.

摘要

使用环磷酰胺（CP）及其代谢产物比较兔淋巴细胞在体内和体外的染色体畸变（CA）率和姐妹染色单体交换（SCE）率。细胞遗传学效应率的剂量依赖性增加在体内和体外实验中，对于SCE和CA似乎分别呈线性和指数依赖性。体内和体外实验的回归方程系数一致。

相似文献

1
[Ratio of the frequency of chromosome aberrations and sister chromatid exchanges to the dose of the mutagenic exposure to cyclophosphamide in vivo and in vitro].[体内和体外染色体畸变及姐妹染色单体交换频率与环磷酰胺诱变暴露剂量的比值]
Biull Eksp Biol Med. 1986 Apr;101(4):461-3.
2
[Comparison of the level of sister chromatid exchanges and chromosome aberrations induced by chemical mutagens in vitro and in vivo].
Tsitol Genet. 1985 Jan-Feb;19(1):20-3.
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[Comparison of the cytogenetic effects of cyclophosphamide on monkey lymphocytes in vivo and in vitro].[环磷酰胺对猴淋巴细胞体内外细胞遗传学效应的比较]
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Cytogenetic effects of cyclophosphamide on human lymphocytes in vivo and in vitro.环磷酰胺对人淋巴细胞的体内及体外细胞遗传学效应。
Mutat Res. 1986 Jan-Feb;159(1-2):103-7. doi: 10.1016/0027-5107(86)90118-1.
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[Quantitative evaluation of the effectiveness of the formation of sister chromatid exchanges and chromosome aberrations as affected by chemical mutagens].[化学诱变剂对姐妹染色单体交换和染色体畸变形成有效性的定量评估]
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[Changes in the occurrence of cytogenetic effects after mutagenic exposure in vivo].
Biull Eksp Biol Med. 1983 Nov;96(11):91-3.
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[Dynamics of the frequencies of sister chromatid exchange and chromosome aberrations in vivo].[体内姐妹染色单体交换频率与染色体畸变的动力学]
Biull Eksp Biol Med. 1988 Aug;106(8):220-1.
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[Quantitative comparison of the cytogenetic effect of thiophosphamide during in vivo and in vitro action on monkey lymphocytes].[硫代磷酰胺在体内和体外作用于猴淋巴细胞时细胞遗传学效应的定量比较]
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Mouse peritoneal lymphocytes, a new target for analyzing induction of sister chromatid exchanges on in vivo exposure to a genotoxic agent.
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Yi Chuan Xue Bao. 1994;21(1):1-6.