College of Environment, Zhejiang University of Technology, Hangzhou 310032, China.
College of Environment, Zhejiang University of Technology, Hangzhou 310032, China.
Sci Total Environ. 2023 Dec 1;902:165942. doi: 10.1016/j.scitotenv.2023.165942. Epub 2023 Aug 4.
The atmosphere is an important reservoir and habitat for antibiotic resistance genes (ARGs) and is a main pathway to cause potential health risks through inhalation and ingestion. However, the distribution characteristics of ARGs in the atmosphere and whether they were driven by atmospheric pollutants remain unclear. We annotated 392 public air metagenomic data worldwide and identified 1863 ARGs, mainly conferring to tetracycline, MLS, and multidrug resistance. We quantified these ARG's risk to human health and identified their principal pathogenic hosts, Burkholderia and Staphylococcus. Additionally, we found that bacteria in particulate contaminated air carry more ARGs than in chemically polluted air. This study revealed the influence of typical pollutants in the global atmosphere on the dissemination and risk of ARGs, providing a theoretical basis for the prevention and mitigation of the global risks associated with ARGs.
大气是抗生素耐药基因（ARGs）的重要储存库和栖息地，也是通过吸入和摄入导致潜在健康风险的主要途径。然而，大气中 ARGs 的分布特征以及它们是否受到大气污染物的驱动尚不清楚。我们注释了全球 392 份公共空气宏基因组数据，鉴定出 1863 个 ARGs，主要赋予四环素、MLS 和多药耐药性。我们量化了这些 ARG 对人类健康的风险，并确定了其主要的致病宿主，伯克霍尔德氏菌和葡萄球菌。此外，我们发现颗粒污染空气中的细菌携带的 ARGs 比化学污染空气中的多。本研究揭示了典型污染物在全球大气中的影响对 ARGs 的传播和风险，为预防和减轻与 ARGs 相关的全球风险提供了理论依据。
