Xiu Leshan, Hu Shuangqing
State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, Shanghai Academy of Environment Sciences, Shanghai 200240, China.
School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Sci One Health. 2025 Jul 4;4:100118. doi: 10.1016/j.soh.2025.100118. eCollection 2025.
Air pollution and antimicrobial resistance (AMR) are two critical challenges that threaten global health and sustainability. Emerging research suggests a significant connection between these phenomena, with air pollution potentially acting as a driver for the development, dissemination, and persistence of antimicrobial resistance genes (ARGs). Drawing on evidence from recent studies, we highlight the mechanisms through which air pollution contributes to AMR, including the role of particulate matter, atmospheric transport, and co-selection pressure. We advocate for a comprehensive One Health approach to address the intertwined threats of air pollution and AMR, emphasizing the need for integrated policies, surveillance, and interdisciplinary research.
空气污染和抗菌药物耐药性(AMR)是威胁全球健康与可持续发展的两大关键挑战。新出现的研究表明,这些现象之间存在重大联系,空气污染可能是抗菌药物耐药基因(ARGs)产生、传播和持续存在的一个驱动因素。基于近期研究的证据,我们强调了空气污染导致抗菌药物耐药性的机制,包括颗粒物、大气传输和共选择压力的作用。我们主张采取全面的“同一健康”方法来应对空气污染和抗菌药物耐药性这两个相互交织的威胁,强调需要制定综合政策、进行监测以及开展跨学科研究。