Toyofuku T, Kubo K, Kobayashi T, Kusama S
Prostaglandins. 1986 Feb;31(2):271-81. doi: 10.1016/0090-6980(86)90053-5.
To determine the role of platelet-activating factor (PAF) in endotoxin shock, we studied the effects of ONO-6240, a PAF antagonist, on endotoxin shock in unanesthetized sheep. Changes in hemodynamics, lung lymph balance, leukocyte and platelet counts, and arterial blood gas tensions were measured in four groups; endotoxin alone; endotoxin plus ONO-6240; ONO-6240 alone; vehicle control. Pretreatment with ONO-6240 in sheep given endotoxin significantly prevented the decreases in systemic arterial pressure, left atrial pressure and cardiac output observed in sheep given endotoxin alone. A partial effect on diminishing the magnitude of peripheral leukopenia was also noted. However, pretreatment with ONO-6240 had little effect on pulmonary hypertension and lung lymph balance. We conclude that endotoxin causes two different effects: vascular collapse and direct lung injury; and that PAF is involved only in the circulatory manifestations.
为确定血小板活化因子（PAF）在内毒素休克中的作用，我们研究了PAF拮抗剂ONO - 6240对未麻醉绵羊内毒素休克的影响。在四组中测量了血流动力学、肺淋巴平衡、白细胞和血小板计数以及动脉血气张力的变化；单独使用内毒素组；内毒素加ONO - 6240组；单独使用ONO - 6240组；溶剂对照组。在内毒素处理的绵羊中，用ONO - 6240预处理可显著防止单独给予内毒素的绵羊出现的体循环动脉压、左心房压和心输出量降低。还注意到对减轻外周白细胞减少程度有部分作用。然而，用ONO - 6240预处理对肺动脉高压和肺淋巴平衡影响不大。我们得出结论，内毒素会产生两种不同的效应：血管塌陷和直接肺损伤；并且PAF仅参与循环系统表现。
