利福平耐药与结核病宿主免疫：远非表面所见。
Rifampicin drug resistance and host immunity in tuberculosis: more than meets the eye.
机构信息
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA.
Department of Microbiology, University of Chicago, Chicago, IL 60637, USA.
出版信息
Trends Immunol. 2023 Sep;44(9):712-723. doi: 10.1016/j.it.2023.07.003. Epub 2023 Aug 3.
Abstract
Tuberculosis (TB) is the leading cause of death due to an infectious agent, with more than 1.5 million deaths attributed to TB annually worldwide. The global dissemination of drug resistance across Mycobacterium tuberculosis (Mtb) strains, causative of TB, resulted in an estimated 450 000 cases of drug-resistant (DR) TB in 2021. Dysregulated immune responses have been observed in patients with multidrug resistant (MDR) TB, but the effects of drug resistance acquisition and impact on host immunity remain obscure. In this review, we compile studies that span aspects of altered host-pathogen interactions and highlight research that explores how drug resistance and immunity might intersect. Understanding the immune processes differentially induced during DR TB would aid the development of rational therapeutics and vaccines for patients with MDR TB.
摘要
结核病（TB）是由感染因子导致的主要死亡原因，全球每年有超过 150 万人因结核病而死亡。结核分枝杆菌（Mtb）菌株的全球耐药性传播导致 2021 年估计有 45 万例耐药结核病（DR-TB）。在耐多药结核病（MDR-TB）患者中观察到免疫反应失调，但耐药性获得及其对宿主免疫的影响仍不清楚。在这篇综述中，我们汇编了研究耐药结核病中宿主-病原体相互作用改变的各个方面，并强调了探索耐药性和免疫如何相互交叉的研究。了解 DR-TB 期间诱导的免疫过程差异将有助于为 MDR-TB 患者开发合理的治疗方法和疫苗。
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