Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Department of Internal Medicine, Texas Tech Health Sciences Center, El Paso, TX.
Semin Nephrol. 2023 Mar;43(2):151406. doi: 10.1016/j.semnephrol.2023.151406. Epub 2023 Aug 4.
Dietary intervention is an essential factor in managing a multitude of chronic health conditions such as cardiovascular and chronic kidney disease. In recent decades, there has been a host of research suggesting the potential benefit of plant-based diets in mitigating the health outcomes of these conditions. Plant-based diets are rich in vegetables and fruits, while limiting processed food and animal protein sources. The underlying physiological mechanism involves the interaction of several macronutrients and micronutrients such as plant protein, carbohydrates, and dietary potassium. Specifically, plant-based foods rich in potassium provide cardiorenal protective effects to include urinary alkalization and increased sodium excretion. These diets induce adaptive physiologic responses that improve kidney and cardiovascular hemodynamics and improve overall metabolic health. A shift toward consuming plant-based diets even in subjects with cardiorenal decrements may reduce their morbidity and mortality. Nonetheless, randomized controlled trials are needed to confirm the clinical benefits of plant-based diets.
饮食干预是管理多种慢性健康状况(如心血管疾病和慢性肾病)的重要因素。近几十年来,大量研究表明,植物性饮食在减轻这些疾病的健康后果方面具有潜在益处。植物性饮食富含蔬菜和水果,同时限制加工食品和动物蛋白来源。其潜在的生理机制涉及几种宏量营养素和微量营养素的相互作用,如植物蛋白、碳水化合物和膳食钾。具体来说,富含钾的植物性食物具有心脏和肾脏保护作用,包括尿液碱化和增加钠排泄。这些饮食诱导适应性生理反应,改善肾脏和心血管血液动力学,改善整体代谢健康。即使在心脏和肾脏功能下降的患者中,转向植物性饮食也可能降低其发病率和死亡率。尽管如此,仍需要随机对照试验来证实植物性饮食的临床益处。