Department of Toxicology, Hebei Medical University, Shijiazhuang, 050017, Hebei, PR China; Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, 050017, PR China.
Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, 050017, PR China.
Environ Pollut. 2023 Oct 15;335:122324. doi: 10.1016/j.envpol.2023.122324. Epub 2023 Aug 5.
Accumulating evidence has suggested that men exposed to air pollution are associated with decreased sperm quality, and seminal plasma plays a pivotal role in maintaining sperm viability. However, the role of seminal plasma in air pollution related sperm quality decline remain unestablished. In current study, we recruited 524 participants from couples who underwent in vitro fertilization treatment due to female factors at a fertility clinic in China from March to August 2020. Conventional sperm parameters, total antioxidant capacity (T-AOC), malondialdehyde (MDA) and testosterone were measured using semen samples. The six main air pollutants (PM, PM, NO, SO, CO, O) during four key periods of sperm development (meiotic stage, spermiogenesis stage, epididymal stage and total sperm cycle period) were estimated using inverse distance weighting method. Multiple linear regression models were employed to investigate the exposure-outcome relationships. And we found that PM exposures were negatively related to sperm total motility and the exposures of PM and PM were inversely associated with sperm progressive motility during epididymal stage. Furthermore, PM and PM exposures were positively associated with seminal plasma MDA and PM was negatively related to seminal plasma T-AOC during epididymal stage. PM, PM and CO exposures during total sperm cycle period might relate to increased seminal plasma testosterone. Mediation analysis indicated seminal plasma MDA and T-AOC partially mediated PM associated reduction of sperm motility during epididymal stage. Our study suggested MDA and T-AOC of seminal plasma played a role in air pollution associated decline of sperm motility.
越来越多的证据表明，暴露于空气污染环境中的男性的精子质量下降，而精浆在维持精子活力方面起着关键作用。然而，精浆在与空气污染相关的精子质量下降中的作用仍未确定。在目前的研究中，我们招募了 524 名参与者，他们来自于中国一家生育诊所，由于女性因素而进行体外受精治疗。使用精液样本测量常规精子参数、总抗氧化能力 (T-AOC)、丙二醛 (MDA) 和睾酮。使用反距离加权法估计了精子发生的四个关键时期（减数分裂阶段、精子形成阶段、附睾阶段和总精子周期）的六种主要空气污染物（PM、PM、NO、SO、CO、O）。采用多元线性回归模型探讨暴露与结果之间的关系。我们发现，PM 暴露与精子总活力呈负相关，PM 和 PM 暴露与附睾阶段精子前向运动呈负相关。此外，PM 和 PM 暴露与附睾阶段精浆 MDA 呈正相关，PM 与附睾阶段精浆 T-AOC 呈负相关。总精子周期期间的 PM、PM 和 CO 暴露可能与增加的精浆睾酮有关。中介分析表明，附睾阶段 PM 相关的精子活力下降部分通过精浆 MDA 和 T-AOC 介导。我们的研究表明，精浆 MDA 和 T-AOC 在与空气污染相关的精子活力下降中起作用。
