Simões Júlia Leão Batista, Braga Geórgia de Carvalho, Mittelmann Tamíres Hillesheim, Bagatini Margarete Dulce
Medical School, Federal University of Fronteira Sul, Chapecó, SC, Brazil.
Graduate Program in Medical Sciences, Federal University of Fronteira Sul, Chapecó, SC, Brazil.
Curr Probl Cardiol. 2024 Jan;49(1 Pt A):102019. doi: 10.1016/j.cpcardiol.2023.102019. Epub 2023 Aug 5.
Studies show that with the COVID-19 pandemic, the world's population went through multiple stress and anxiety factors, generating serious psychological problems, in addition, the virus also caused damage and physical stress to those contaminated. In this way, the intense emotional experiences and stressful effects on the body caused by SARS-CoV-2 are capable of triggering the excessive release of catecholamines in the body. Thus, the framework of Takotsubo Syndrome is characterized by myocardial dysfunction as a response of cardiac receptors to the spillage of such hormones in an unregulated way in the human body. The purinergic system plays a central role in this process, as it actively participates in actions responsible for the syndromic cascade, such as the stress generated by the cytokine storm triggered by the virus and the stimulation of deregulated catecholamine release. Therefore, further pharmacological studies on the role of purines in this pathology should be developed in order to avoid the evolution of the syndrome and to modulate its P1 and P2 receptors aiming at developing means of reversing or treating the Takotsubo Syndrome.
研究表明，在新冠疫情期间，世界人口经历了多种压力和焦虑因素，引发了严重的心理问题，此外，该病毒还对感染者造成了损害和身体压力。这样一来，由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的强烈情感体验和对身体的压力效应能够触发体内儿茶酚胺的过度释放。因此，应激性心肌病的发病机制以心肌功能障碍为特征，这是心脏受体对这类激素在人体内无节制溢出的一种反应。嘌呤能系统在这一过程中起着核心作用，因为它积极参与导致该综合征一系列反应的活动，如病毒引发的细胞因子风暴所产生的压力以及对失控的儿茶酚胺释放的刺激。因此，应进一步开展关于嘌呤在这种病理状态中作用的药理学研究，以避免该综合征的进展，并调节其P1和P2受体，旨在开发出逆转或治疗应激性心肌病的方法。
