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登革病毒蚊虫分离株与鸭源分离株在雏鸭和 3 周龄小鼠体内的致病性比较研究。

Comparative study of the pathogenicity of the mosquito origin strain and duck origin strain of Tembusu virus in ducklings and three-week-old mice.

机构信息

Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China.

Institute of Technology, University of Tartu, Tartu, 999148, Estonia.

出版信息

Virol Sin. 2023 Oct;38(5):827-831. doi: 10.1016/j.virs.2023.07.006. Epub 2023 Aug 5.

DOI:10.1016/j.virs.2023.07.006
PMID:37544649
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10590687/
Abstract

• TMUV can infect Kunming mice by i.c., and the pathogenicity of mosquito TMUV is higher than that of duck TMUV. • TMUV can infect SPF ducklings by i.m., and the pathogenicity of duck TMUV is higher than that of mosquito TMUV. • SPF ducklings infected with mosquito TMUV did not produce viremia at 3, 5 and 7 dpi.

摘要

• TMUV 可通过脑内感染昆明系小鼠,且蚊源 TMUV 的致病性高于鸭源 TMUV。 • TMUV 可通过肌肉感染 SPF 雏鸭,且鸭源 TMUV 的致病性高于蚊源 TMUV。 • 感染蚊源 TMUV 的 SPF 雏鸭在 3、5 和 7 dpi 时均未产生血传病毒。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dce6/10590687/c574d40d35db/gr1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dce6/10590687/c574d40d35db/gr1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dce6/10590687/c574d40d35db/gr1a.jpg

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本文引用的文献

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Stem-Loop I of the Tembusu Virus 3'-Untranslated Region Is Responsible for Viral Host-Specific Adaptation and the Pathogenicity of the Virus in Mice.柄环 I 是 Tembusu 病毒 3'非翻译区负责病毒宿主特异性适应和病毒在小鼠中的致病性。
Microbiol Spectr. 2022 Oct 26;10(5):e0244922. doi: 10.1128/spectrum.02449-22. Epub 2022 Oct 10.
2
Construction of an Infectious Clone for Mosquito-Derived Tembusu Virus Prototypical Strain.蚊源坦布苏病毒原型株感染性克隆的构建
Virol Sin. 2021 Dec;36(6):1678-1681. doi: 10.1007/s12250-021-00447-y. Epub 2021 Sep 27.
3
Tembusu Virus entering the central nervous system caused nonsuppurative encephalitis without disrupting the blood-brain barrier.
登革病毒进入中枢神经系统会引发非化脓性脑炎,且不会破坏血脑屏障。
J Virol. 2021 Mar 10;95(7). doi: 10.1128/JVI.02191-20. Epub 2021 Jan 20.
4
Pathogenesis of Thai duck Tembusu virus in BALB/c mice: Descending infection and neuroinvasive virulence.泰国鸭坦布苏病毒在BALB/c小鼠中的发病机制:下行感染和神经侵袭性毒力。
Transbound Emerg Dis. 2021 Nov;68(6):3529-3540. doi: 10.1111/tbed.13958. Epub 2020 Dec 30.
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The Role of Microglia during West Nile Virus Infection of the Central Nervous System.小胶质细胞在西尼罗河病毒感染中枢神经系统过程中的作用
Vaccines (Basel). 2020 Aug 28;8(3):485. doi: 10.3390/vaccines8030485.
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Stabilization of a full-length infectious cDNA clone for duck Tembusu virus by insertion of an intron.通过插入内含子稳定鸭坦布苏病毒全长感染性 cDNA 克隆。
J Virol Methods. 2020 Sep;283:113922. doi: 10.1016/j.jviromet.2020.113922. Epub 2020 Jun 26.
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