Iwasaki S, Namikoshi M, Kobayashi H, Furukawa J, Okuda S, Itai A, Kasuya A, Iitaka Y, Sato Z
J Antibiot (Tokyo). 1986 Mar;39(3):424-9. doi: 10.7164/antibiotics.39.424.
The absolute structure of rhizoxin, a potent antifungal and antitumor antibiotic, was determined by interrelation with compound 2 whose structure was established by X-ray analysis. Since a 18OH group was introduced at C-3 on a hydrolytic cleavage of C-2, C-3 epoxy group with alkaline H2(18)O, the original epoxy oxygen should be retained at C-2. The stereo-chemistry at C-2 and C-3 positions in rhizoxin was, therefore, determined as 2R,3S.
根霉素是一种有效的抗真菌和抗肿瘤抗生素，其绝对结构是通过与化合物2相关联来确定的，化合物2的结构是通过X射线分析确定的。由于在碱性H2(18)O对C-2、C-3环氧基进行水解裂解时，在C-3位引入了一个18OH基团，因此原来的环氧氧应该保留在C-2位。因此，根霉素中C-2和C-3位的立体化学被确定为2R,3S。
