用于酮α-官能化的手性碘苯胺-乳酸酯基催化剂的合成
Synthesis of Chiral Iodoaniline-Lactate Based Catalysts for the α-Functionalization of Ketones.
作者信息
Alkahtani Rawiyah, Wirth Thomas
机构信息
School of Chemistry, Cardiff University, Main Building, Park Place, CF10 3AT, Cardiff, United Kingdom.
Chemistry Department, College of Science, Princess Nourah bint Abdulrahman University, 11671, Riyadh, Saudi Arabia.
出版信息
ACS Org Inorg Au. 2023 May 9;3(4):209-216. doi: 10.1021/acsorginorgau.3c00012. eCollection 2023 Aug 2.
A family of chiral iodoaniline-lactate based catalysts with and symmetry were efficiently synthesized. Comparisons between the reactivity and selectivity between the new and previously reported catalysts are made. The new catalysts promoted the α-oxysulfonylation of ketones in shorter reaction times and with higher yields of up to 99%. A scope for the oxysulfonylation reaction is presented, forming a variety of reported and novel products with enantioselectivities of up to 83%.
高效合成了一系列具有[具体对称性]对称的手性碘代苯胺 - 乳酸基催化剂。对新型催化剂与先前报道的催化剂的反应活性和选择性进行了比较。新型催化剂能在更短的反应时间内促进酮的α - 氧磺酰化反应，产率高达99%。展示了氧磺酰化反应的适用范围，形成了多种已报道的和新型产物，对映选择性高达83%。
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