Department of Pharmacy, Seventh-Day Adventist Hospital-Kwadaso.
Department of Pharmacology, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Afr Health Sci. 2023 Mar;23(1):417-428. doi: 10.4314/ahs.v23i1.44.
Infant mortality remains a major developmental challenge in many low-income countries. Epidemiological evidence suggests that infant acquisition of maternal microbiome is essential for programming of immunity and metabolism. As such, irrational maternal antibiotic use may affect infant health.
The aim of the study was to determine the effects of prenatal antibiotic use on early postnatal life (90 days) in a low-income community in Ghana.
The study was a retrospective study of 412 mother-baby pair medical records in a low-income community in rural Ghana.
During the ninety-day period, the prevalence and relative risk of neonatal sepsis, respiratory disorders, and dermatitis were significantly higher in infants treated prenatally with antibiotics compared to untreated infants. Prenatal antibiotic treatment was not significantly associated with the risk of developing neonatal jaundice and conjunctivitis. However, prenatally antibiotic exposed infants were three times likely to visit the hospital for a non-scheduled/non-review treatment within the first 90 days compared to unexposed babies.
Intrapartum antibiotic treatment is associated with poor early infant health. Rationalizing antibiotic use during pregnancy may contribute to reducing infant mortality.
婴儿死亡率仍然是许多低收入国家面临的主要发展挑战。流行病学证据表明，婴儿获得母体微生物组对于免疫和代谢的编程至关重要。因此，不合理的母亲使用抗生素可能会影响婴儿的健康。
本研究旨在确定在加纳农村的一个低收入社区中，产前使用抗生素对婴儿出生后 90 天内的影响。
这是一项在加纳农村的一个低收入社区中对 412 对母婴医疗记录进行的回顾性研究。
在 90 天的时间内，与未接受治疗的婴儿相比，产前接受抗生素治疗的新生儿败血症、呼吸障碍和皮炎的患病率和相对风险显著更高。产前抗生素治疗与新生儿黄疸和结膜炎的发病风险无显著相关性。然而，与未暴露于抗生素的婴儿相比，产前接受抗生素治疗的婴儿在出生后的前 90 天内更有可能因非计划/非复查治疗而三次到医院就诊。
分娩时使用抗生素与婴儿早期健康状况不佳有关。在怀孕期间合理使用抗生素可能有助于降低婴儿死亡率。
