Alburayk Khalid B, Alghamdi Saleh S, Alsubaie Musab A, Alghamdi Wejdan S, Alzaher Fatimah, Alsomali Abdulaziz I
Department of Ophthalmology, King Fahd Hospital of the University, Imam Abdulrahman Al Faisal University, Dammam, SAU.
Department of Ophthalmology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, SAU.
Cureus. 2023 Jul 6;15(7):e41446. doi: 10.7759/cureus.41446. eCollection 2023 Jul.
The purpose of this report is to provide a comprehensive account of an exceptional case involving the presentation of congenital rubella syndrome (CRS) in a newborn. Furthermore, it aims to document the successful regression of CRS through medical treatment alone. We present the case of a five-day-old infant who was referred to our facility as a CRS case. The patient presented with bilateral white corneal opacity, which was observed shortly after birth. The mother was diagnosed as rubella-positive during pregnancy. Upon the initial examination under anesthesia, both eyes exhibited central white corneal opacity accompanied by large intrastromal cysts. Although a few breaks in Descemet's membrane were observed in both eyes, there were no signs of vascularization or the presence of iridocorneal or lenticular-corneal adhesions. After undergoing medical treatment consisting of topical sodium chloride and steroids, the cysts in both eyes completely regressed. Subsequently, the patient underwent penetrating keratoplasty to further address the dense scar. This case enhances our comprehension of ophthalmological complications associated with CRS and provides valuable insights into alternative therapeutic approaches for corneal stromal cysts.
本报告的目的是全面介绍一例新生儿先天性风疹综合征（CRS）的特殊病例。此外，其旨在记录仅通过药物治疗使CRS成功消退的情况。我们报告一例五天大的婴儿，该婴儿作为CRS病例被转诊至我院。患儿出生后不久即出现双侧白色角膜混浊。母亲在孕期被诊断为风疹阳性。在首次麻醉下检查时，双眼均表现为中央白色角膜混浊并伴有大量基质内囊肿。虽然双眼均观察到后弹力层有几处破裂，但未发现血管化迹象，也没有虹膜角膜或晶状体角膜粘连。在接受局部氯化钠和类固醇药物治疗后，双眼囊肿完全消退。随后，患儿接受了穿透性角膜移植术以进一步处理致密瘢痕。该病例增进了我们对与CRS相关的眼科并发症的理解，并为角膜基质囊肿的替代治疗方法提供了有价值的见解。
