Bhaskar Lakshmi, Kharya Chhaya, Debnath Monojith, Mullapudi Thrinath, Subbanna Manjula, Chhabra Deepika, Kumar Neeta, Sharma Prem Prakash, Bhagat Om Lata, Kochupillai Vinod
Sri Sri Institute for Advanced Research, Ved Vignan Maha Vidya Peeth, Bengaluru, IND.
Department of Human Genetics, National Institute of Mental Health and Neurosciences, Bengaluru, IND.
Cureus. 2023 Jul 4;15(7):e41377. doi: 10.7759/cureus.41377. eCollection 2023 Jul.
Background Stress leads to immune system dysregulation and dyshomeostasis at the gene level. Mind-body practices are known to influence genomic expression, leading to better health and quality of life. Objective To assess the effect of Advanced Meditation Program (AMP) on the mRNA expression of pro-inflammatory and antioxidative genes among those already practicing Sudarshan Kriya Yoga (SKY). Methods A total of 97 healthy volunteers participated in the study, distributed into two groups. The Group I SKY practitioners attended a four-day AMP (50 participants with an average age of 38.8 ± 11.9 consisting of 37 females and 13 males); they are first-time participants of the AMP. Group II SKY practitioners, on the other hand, consisted of 47 participants with an average age of 36.4 ± 9.3 with 43 females and four males. At day 0, day 5, and day 90, the mRNA expression of pro-inflammatory genes, namely interleukin (IL) 1β, IL6, and the tumor necrosis factor (TNF), and the expression of antioxidative genes, namely superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) was observed. The data were analysed in two phases due to the emergence of coronavirus disease 2019 (COVID-19): (i) pre-COVID-19 and (ii) during COVID-19. Results In the pre-COVID-19 data set, IL1β, IL6, and TNF were found to have decreased in both groups. There is a significant increase in the expression of SOD and catalase in Group I and a decrease in Group II by day 90. During COVID-19, pro-inflammatory genes increased in Group I and had no significant change in Group II. All three antioxidant genes had decreased expression by day 90 in Group I; SOD decreased in Group II. Interpretation and conclusions Reduced expression of pro-inflammatory genes and increase in the expression of antioxidative genes during the pre-COVID-19 time suggest that the practice of SKY and added AMP may enhance antioxidative defense and may reduce the chance of getting diseases related to inflammation in the body.
压力会导致免疫系统在基因水平上失调和内环境稳态失衡。身心锻炼方法已知会影响基因组表达，从而带来更好的健康和生活质量。目的：评估高级冥想计划（AMP）对已在练习苏达山克里亚瑜伽（SKY）者体内促炎和抗氧化基因的mRNA表达的影响。方法：共有97名健康志愿者参与研究，分为两组。第一组SKY练习者参加了为期四天的AMP（50名参与者，平均年龄38.8±11.9岁，其中37名女性和13名男性）；他们是AMP的首次参与者。另一方面，第二组SKY练习者由47名参与者组成，平均年龄36.4±9.3岁，其中43名女性和4名男性。在第0天、第5天和第90天，观察促炎基因白细胞介素（IL）1β、IL6和肿瘤坏死因子（TNF）的mRNA表达以及抗氧化基因超氧化物歧化酶（SOD）、过氧化氢酶和谷胱甘肽过氧化物酶（GPx）的表达。由于2019冠状病毒病（COVID-19）的出现，数据分两个阶段进行分析：（i）COVID-19之前；（ii）COVID-19期间。结果：在COVID-19之前的数据集中，两组的IL1β、IL6和TNF均有所下降。到第90天时，第一组SOD和过氧化氢酶的表达显著增加，第二组则下降。在COVID-19期间，第一组促炎基因增加，第二组无显著变化。到第90天时，第一组所有三种抗氧化基因的表达均下降；第二组SOD下降。解读与结论：在COVID-19之前，促炎基因表达降低，抗氧化基因表达增加，这表明SKY练习加上AMP可能增强抗氧化防御，并可能降低患身体炎症相关疾病的几率。
