Janjanam Vimala Devi, Ewart Susan, Zhang Hongmei, Jiang Yu, Arshad Hasan, Ziyab Ali H, Karmaus Wilfried
Division of Epidemiology, Biostatistics, and Environmental Health School of Public Health University of Memphis Memphis Tennessee USA.
Department of Large Animal Clinical Sciences Michigan State University East Lansing Michigan USA.
Obes Sci Pract. 2023 Jan 9;9(4):424-434. doi: 10.1002/osp4.660. eCollection 2023 Aug.
To date, epigenetic studies identified differential DNA methylation (DNAm) related to gestational-body mass index (BMI) in offspring at birth. This study investigated whether the identified DNAm in offspring were also associated with BMI trajectories from infancy to age 26 years.
Data of 794 participants from Isle of Wight birth cohort in UK were investigated to study association between BMI trajectories and DNAm related to gestational-BMI at birth. Multinominal logistic regression models were applied to test the association between 1090 DNAm sites reported in three prior epigenome-wide association studies and BMI trajectories.
DNAm site cg23089913 () and cg13217064 () were associated with early persistent obesity (EPO) and delayed overweight (DOW) trajectories respectively. A higher methylation of cg23089913 showed low odds of being in EPO trajectory (OR: 0.84; 95% CI: 0.76-0.93) while higher methylation of cg13217064 resulted in 1.4-times the odds of being in DOW trajectory when compared to the normal trajectory [Correction added on 22 February 2023, after first online publication: Range of the DNAm site cg23089913 has been changed from 'lower' to 'higher' in the preceding sentence.]. In a gender-stratified analysis, the odds of developing into DOW was 1.8 times in female participants for cg13217064 while not such association was observed in males.
Deviations in methylation of cg23089913 () and cg13217064 () in newborns may change the risk of having excess body weight.
迄今为止，表观遗传学研究已确定出生时后代的DNA甲基化（DNAm）差异与孕期体重指数（BMI）有关。本研究调查了所确定的后代DNAm是否也与从婴儿期到26岁的BMI轨迹相关。
对来自英国怀特岛出生队列的794名参与者的数据进行研究，以探讨BMI轨迹与出生时与孕期BMI相关的DNAm之间的关联。应用多项逻辑回归模型来检验三项先前全表观基因组关联研究中报告的1090个DNAm位点与BMI轨迹之间的关联。
DNAm位点cg23089913（）和cg13217064（）分别与早期持续性肥胖（EPO）和延迟性超重（DOW）轨迹相关。cg23089913甲基化程度较高表明处于EPO轨迹的几率较低（比值比：0.84；95%置信区间：0.76 - 0.93），而与正常轨迹相比，cg13217064甲基化程度较高导致处于DOW轨迹的几率增加1.4倍[2023年2月22日首次在线发表后添加的更正：前一句中DNAm位点cg23089913的范围已从“较低”改为“较高”]。在按性别分层的分析中，对于cg13217064，女性参与者发展为DOW的几率是男性的1.8倍，而在男性中未观察到这种关联。
新生儿中cg23089913（）和cg13217064（）的甲基化偏差可能会改变超重的风险。
